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Abstract：
To evaluate the usability of platelet mass index (PMI) thresholds to assess the repeated platelet transfusion requirements in neonates who have received transfusion within the previous six days. This is a retrospective cross-sectional study conducted with neonates who received prophylactic platelet transfusion. The PMI was calculated as platelet count (× 1000/mm3) × mean platelet volume (MPV) (fL). Platelet transfusions were divided into two groups as first (Group 1) and repeated transfusions (Group 2). The increment and percentage of increment in platelet counts, MPV and PMI after transfusion were compared between the two groups. The amounts of changes were calculated as: (Post-transfusion) - (Pre-transfusion values). The percentages of changes were calculated as: ([Post-transfusion - Pre-transfusion values]/Pre-tansfusion values) × 100. Eighty three platelet transfusions were analyzed in 28 neonates. The median gestational age and birth weight were 34.5 (26-37) weeks, and 2225 (752.5-2937.5) grams, respectively. There were 20 (24.1%) transfusions in Group 1, and 63 (75.9%) transfusions in Group 2. There were no differences in the amounts of changes in platelet counts, MPV and PMI between the groups (p > 0.05). When the percentages of changes were analyzed, it was found that the platelet counts and PMI in Group 1 increased to a greater extent compared to Group 2 (p = 0.026, p = 0.039, respectively), but no significant difference was found in MPV between the groups (p = 0.081). The lower percentage of change in PMI in Group 2 was associated with the lower percentage of change in platelet counts. Being transfused with adult platelets did not affect platelet volume of the neonates. Therefore, PMI thresholds can be used in neonates with a history of platelet transfusion.
摘要：
评估血小板质量指数（PMI）阈值的可用性，以评估在过去六天内接受输血的新生儿的重复血小板输注需求。这是一项对接受预防性血小板输注的新生儿进行的回顾性横断面研究。PMI计算为血小板计数（×1000/mm3）×平均血小板体积（MPV）（fL）。血小板输注分为两组，分别为第一组（第1组）和重复输注（第2组）。血小板计数的增量和增量百分比，比较两组患者输血后的MPV和PMI。变化的量计算为:(输血后)-(输血前值)。变化的百分比计算为:([输血后-输血前值]/输血前值)×100。对28例新生儿83例进行血小板输注分析。中位胎龄和出生体重为34.5(26-37)周,和2225（752.5-2937.5）克，分别。第1组中有20例（24.1％）输血，第2组中有63例（75.9％）输血。血小板计数的变化量没有差异，MPV和PMI组间比较(p>0.05)。当分析变化的百分比时，发现与第2组相比，第1组的血小板计数和PMI增加幅度更大（分别为p=0.026，p=0.039），但两组间MPV无显著差异(p=0.081)。第2组PMI变化百分比较低与血小板计数变化百分比较低相关。输注成人血小板不会影响新生儿的血小板体积。因此,PMI阈值可用于有血小板输血史的新生儿。
