PDF(Pubmed)
Abstract：
In recent years, the unique and diverse physicochemical properties of nanoparticles have brought about their wide use in many fields; however, it is necessary to better understand the possible human health risks caused by their release in the environment. Although the adverse health effects of nanoparticles have been proposed and are still being clarified, their effects on lung health have not been fully studied. In this review, we focus on the latest research progress on the pulmonary toxic effects of nanoparticles, and we summarized their disturbance of the pulmonary inflammatory response. First, the activation of lung inflammation by nanoparticles was reviewed. Second, we discussed how further exposure to nanoparticles aggravated the ongoing lung inflammation. Third, we summarized the inhibition of the ongoing lung inflammation by nanoparticles loaded with anti-inflammatory drugs. Forth, we introduced how the physicochemical properties of nanoparticles affect the related pulmonary inflammatory disturbance. Finally, we discussed the main gaps in current research and the challenges and countermeasures in future research.
摘要：
近年来,纳米粒子独特多样的物理化学性质使其在许多领域得到了广泛的应用,有必要更好地了解它们在环境中的释放可能对人类健康造成的风险。尽管纳米粒子对健康的不利影响已经被提出并且仍在澄清中，它们对肺部健康的影响尚未得到充分研究。在这次审查中,我们关注纳米粒子对肺毒性作用的最新研究进展，我们总结了他们对肺部炎症反应的干扰。首先,综述了纳米颗粒对肺部炎症的激活作用。第二,我们讨论了进一步暴露于纳米颗粒如何加重持续的肺部炎症.第三，我们总结了负载抗炎药物的纳米颗粒对正在进行的肺部炎症的抑制作用。Forth,我们介绍了纳米颗粒的理化性质如何影响相关的肺部炎症紊乱。最后,我们讨论了当前研究的主要差距以及未来研究的挑战和对策。
