PDF(Pubmed)
Abstract：
BACKGROUND: Neurofibromatosis (NF) is an inherited disease and a benign tumor originating from nerve sheath cells. Neurofibromatosis type I (NF1) is the most common type, and most cases are characterized by neurofibromas. Neurofibromas in NF1 are mainly treated by surgery. Our study explores the risk factors for intraoperative hemorrhage in Type I neurofibromatosis patients who underwent neurofibroma resection.
METHODS: A cross-sectional comparison of the patients who had undergone resection of neurofibroma for NF1. Data regarding patient characteristics and data about operative outcomes were recorded. The definition of intraoperative hemorrhage group was the intraoperative blood loss greater than 200 ml.
RESULTS: Of 94 eligible patients, 44 patients were in the hemorrhage group and 50 patients were in the non-hemorrhage group. Multiple logistic regression analysis demonstrated that the area of excision, classification, surgical site, primary surgical, and organ deformation were significant independent predictors of hemorrhage.
CONCLUSIONS: Early treatment can reduce the tumor cross-sectional area, avoid organ deformation, and reduce intraoperative blood loss. For plexiform neurofibroma or neurofibroma of the head and face, the amount of blood loss should be predicted correctly, and preoperative evaluation and blood preparation should be paid more attention to.
METHODS: A cross-sectional comparison of the patients who had undergone resection of neurofibroma for NF1. Data regarding patient characteristics and data about operative outcomes were recorded. The definition of intraoperative hemorrhage group was the intraoperative blood loss greater than 200 ml.
RESULTS: Of 94 eligible patients, 44 patients were in the hemorrhage group and 50 patients were in the non-hemorrhage group. Multiple logistic regression analysis demonstrated that the area of excision, classification, surgical site, primary surgical, and organ deformation were significant independent predictors of hemorrhage.
CONCLUSIONS: Early treatment can reduce the tumor cross-sectional area, avoid organ deformation, and reduce intraoperative blood loss. For plexiform neurofibroma or neurofibroma of the head and face, the amount of blood loss should be predicted correctly, and preoperative evaluation and blood preparation should be paid more attention to.
摘要：
背景：神经纤维瘤病（NF）是一种遗传性疾病，是一种起源于神经鞘细胞的良性肿瘤。神经纤维瘤病I型（NF1）是最常见的类型，大多数病例以神经纤维瘤为特征。NF1中的神经纤维瘤主要通过手术治疗。我们的研究探讨了接受神经纤维瘤切除术的I型神经纤维瘤病患者术中出血的危险因素。
方法：接受NF1切除神经纤维瘤的患者的横断面比较。记录有关患者特征的数据和有关手术结果的数据。术中出血组的定义是术中出血量大于200ml。
结果：在94名符合条件的患者中，出血组44例，非出血组50例。多元logistic回归分析表明，切除面积，分类，手术部位,初级外科,器官变形是出血的独立预测因子。
结论：早期治疗可以减小肿瘤横截面积，避免器官变形，减少术中失血。对于丛状神经纤维瘤或头部和面部的神经纤维瘤，应该正确预测失血量，术前评估和血液准备应更加重视。
方法：接受NF1切除神经纤维瘤的患者的横断面比较。记录有关患者特征的数据和有关手术结果的数据。术中出血组的定义是术中出血量大于200ml。
结果：在94名符合条件的患者中，出血组44例，非出血组50例。多元logistic回归分析表明，切除面积，分类，手术部位,初级外科,器官变形是出血的独立预测因子。
结论：早期治疗可以减小肿瘤横截面积，避免器官变形，减少术中失血。对于丛状神经纤维瘤或头部和面部的神经纤维瘤，应该正确预测失血量，术前评估和血液准备应更加重视。
