Abstract：
The recent widespread use of diffusion tensor imaging (DTI) tractography allowed researchers to investigate the diffusivity modifications and neuroanatomical changes of white matter (WM) fascicles in major psychiatric disorders, including bipolar disorder (BD). In BD, corpus callosum (CC) seems to have a crucial role in explaining the pathophysiology and cognitive impairment of this psychiatric disorder. This review aims to provide an overview on the latest results emerging from studies that investigated neuroanatomical changes of CC in BD using DTI tractography.
Bibliographic research was conducted on PubMed, Scopus and Web of Science datasets until March 2022. Ten studies fulfilled our inclusion criteria.
From the reviewed DTI tractography studies a significant decrease of fractional anisotropy emerged in the genu, body and splenium of CC of BD patients compared to controls. This finding is coupled with reduction of fiber density and modification in fiber tract length. Finally, an increase of radial and mean diffusivity in forceps minor and in the entire CC was also reported.
Small sample size, heterogeneity in terms of methodological (diffusion gradient) and clinical (lifetime comorbidity, BD status, pharmacological treatments) characteristics.
Overall, these findings suggest the presence of structural modifications in CC in BD patients, which may in turn explain the cognitive impairments often observed in this psychiatric disorder, especially in executive processing, motor control and visual memory. Finally, structural modifications may suggest an impairment in the amount of functional information and a morphological impact within those brain regions connected by CC.
Bibliographic research was conducted on PubMed, Scopus and Web of Science datasets until March 2022. Ten studies fulfilled our inclusion criteria.
From the reviewed DTI tractography studies a significant decrease of fractional anisotropy emerged in the genu, body and splenium of CC of BD patients compared to controls. This finding is coupled with reduction of fiber density and modification in fiber tract length. Finally, an increase of radial and mean diffusivity in forceps minor and in the entire CC was also reported.
Small sample size, heterogeneity in terms of methodological (diffusion gradient) and clinical (lifetime comorbidity, BD status, pharmacological treatments) characteristics.
Overall, these findings suggest the presence of structural modifications in CC in BD patients, which may in turn explain the cognitive impairments often observed in this psychiatric disorder, especially in executive processing, motor control and visual memory. Finally, structural modifications may suggest an impairment in the amount of functional information and a morphological impact within those brain regions connected by CC.
摘要：
背景：最近广泛使用的弥散张量成像（DTI）纤维束成像技术使研究人员能够研究主要精神疾病中白质（WM）束的弥散性修饰和神经解剖学变化，包括双相情感障碍（BD）。在BD,call体（CC）似乎在解释这种精神疾病的病理生理学和认知障碍中起着至关重要的作用。这篇综述旨在概述使用DTI纤维束造影研究BD中CC的神经解剖学变化的研究中出现的最新结果。
方法：在PubMed上进行了书目研究，截至2022年3月的Scopus和WebofScience数据集。10项研究符合我们的纳入标准。
结果：从所审查的DTI纤维束成像研究中，在该地区出现了各向异性分数（FA）的显着降低，与对照组相比，BD患者的CC体和脾。这一发现与纤维密度的降低和纤维束长度的改变有关。最后,还报告了镊子和整个CC的径向（RD）和平均扩散系数（MD）的增加。
结论：样本量小，在方法学(扩散梯度)和临床(终生共病，BD状态,药理治疗）特征。
结论：总体而言，这些发现表明BD患者CC存在结构修饰，这反过来可以解释在这种精神疾病中经常观察到的认知障碍，尤其是在行政处理中，电机控制和视觉记忆。最后,结构修饰可能表明功能信息的数量受损，并且在CC连接的那些大脑区域内存在形态学影响。
方法：在PubMed上进行了书目研究，截至2022年3月的Scopus和WebofScience数据集。10项研究符合我们的纳入标准。
结果：从所审查的DTI纤维束成像研究中，在该地区出现了各向异性分数（FA）的显着降低，与对照组相比，BD患者的CC体和脾。这一发现与纤维密度的降低和纤维束长度的改变有关。最后,还报告了镊子和整个CC的径向（RD）和平均扩散系数（MD）的增加。
结论：样本量小，在方法学(扩散梯度)和临床(终生共病，BD状态,药理治疗）特征。
结论：总体而言，这些发现表明BD患者CC存在结构修饰，这反过来可以解释在这种精神疾病中经常观察到的认知障碍，尤其是在行政处理中，电机控制和视觉记忆。最后,结构修饰可能表明功能信息的数量受损，并且在CC连接的那些大脑区域内存在形态学影响。
