Bibliographic research was conducted on PubMed, Scopus and Web of Science datasets until March 2022. Ten studies fulfilled our inclusion criteria.
From the reviewed DTI tractography studies a significant decrease of fractional anisotropy emerged in the genu, body and splenium of CC of BD patients compared to controls. This finding is coupled with reduction of fiber density and modification in fiber tract length. Finally, an increase of radial and mean diffusivity in forceps minor and in the entire CC was also reported.
Small sample size, heterogeneity in terms of methodological (diffusion gradient) and clinical (lifetime comorbidity, BD status, pharmacological treatments) characteristics.
Overall, these findings suggest the presence of structural modifications in CC in BD patients, which may in turn explain the cognitive impairments often observed in this psychiatric disorder, especially in executive processing, motor control and visual memory. Finally, structural modifications may suggest an impairment in the amount of functional information and a morphological impact within those brain regions connected by CC.
方法:在PubMed上进行了书目研究,截至2022年3月的Scopus和WebofScience数据集。10项研究符合我们的纳入标准。
结果:从所审查的DTI纤维束成像研究中,在该地区出现了各向异性分数(FA)的显着降低,与对照组相比,BD患者的CC体和脾。这一发现与纤维密度的降低和纤维束长度的改变有关。最后,还报告了镊子和整个CC的径向(RD)和平均扩散系数(MD)的增加。
结论:样本量小,在方法学(扩散梯度)和临床(终生共病,BD状态,药理治疗)特征。
结论:总体而言,这些发现表明BD患者CC存在结构修饰,这反过来可以解释在这种精神疾病中经常观察到的认知障碍,尤其是在行政处理中,电机控制和视觉记忆。最后,结构修饰可能表明功能信息的数量受损,并且在CC连接的那些大脑区域内存在形态学影响。