PDF(Pubmed)
Abstract：
Photoresponsive polymers hold vast potential in the realm of drug delivery. Currently, most photoresponsive polymers use ultraviolet (UV) light as the excitation source. However, the limited penetration ability of UV light within biological tissues serves as a significant hindrance to their practical applications. Given the strong penetration ability of red light in biological tissues, the design and preparation of a novel red-light-responsive polymer with high water stability, incorporating the reversible photoswitching compound and donor-acceptor Stenhouse adducts (DASA) for controlled drug release is demonstrated. In aqueous solutions, this polymer exhibits self-assembly into micellar nanovectors (~33 nm hydrodynamic diameter), facilitating the encapsulation of the hydrophobic model drug Nile red (NR) within the micellar core. Upon irradiation by a 660 nm LED light source, photons are absorbed by DASA, leading to the disruption of the hydrophilic-hydrophobic balance of the nanovector and thereby resulting in the release of NR. This newly designed nanovector incorporates red light as a responsive switch, successfully avoiding the problems of photodamage and limited penetration of UV light within biological tissues, thereby further promoting the practical applications of photoresponsive polymer nanomedicines.
摘要：
光响应性聚合物在药物递送领域具有巨大的潜力。目前,大多数光敏聚合物使用紫外(UV)光作为激发源。然而,UV光在生物组织内的有限穿透能力对它们的实际应用起了显著的阻碍作用。鉴于红光在生物组织中的强穿透能力,设计和制备了一种具有高水稳定性的新型红光响应聚合物，证明了将可逆光转换化合物和供体-受体Stenhouse加合物（DASA）结合用于控制药物释放。在水溶液中,这种聚合物表现出自组装成胶束纳米载体（流体动力学直径〜33nm），促进疏水模型药物尼罗红(NR)在胶束核心内的包封。在用660nmLED光源照射时，光子被DASA吸收，导致纳米载体的亲水-疏水平衡的破坏，从而导致NR的释放。这种新设计的纳米载体结合了红光作为响应开关，成功地避免了光损伤和紫外线在生物组织中的有限渗透的问题，从而进一步促进光响应聚合物纳米药物的实际应用。
