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Abstract：
Mature cystic teratoma (MCT) is a benign germ cell tumor, histologically comprising components derived from mesoderm, ectoderm, and endoderm layer tissue. MCT usually has foci of intestinal components and colonic epithelia. Pituitary teratomas containing complete colon features are very rare. Here, we present three cases of sellar teratoma in two men aged 50 and 65 years and a woman aged 30 years. All patients presented with asthenia, adynamia, and loss of strength. A pituitary mass was incidentally observed on magnetic resonance imaging. Histological features showed a mature teratoma formed by gut and colonic epithelium, extended lymphoid tissue with the formation of Peyer\'s patches, and muscular layer vestiges with a fibrous capsule. The immunohistochemical panel showed reactivity to cytokeratin (CK)7, CKAE6/AE7, carcinoembryonic antigen, octamer-binding transcription factor 4, cluster of differentiation (CD)20, CD3, vimentin, muscle actin, and pituitary tumor-transforming gene 1 in isolated cells. However, alpha-fetoprotein, beta-human chorionic gonadotropin, human placental lactogen, CK20, tumor suppressor protein 53, and Kirsten rat sarcoma were negative. This article describes the clinical and histological features of rare sellar masses as well as survival after therapy.
摘要：
成熟囊性畸胎瘤（MCT）是一种良性生殖细胞肿瘤，组织学上包含来自中胚层的成分，外胚层,和内胚层组织。MCT通常具有肠成分和结肠上皮的病灶。包含完整结肠特征的垂体畸胎瘤非常罕见。这里,我们介绍了3例鞍性畸胎瘤病例，其中两名男性年龄分别为50岁和65岁，一名女性年龄为30岁。所有患者都表现为虚弱，adynamia,失去力量。在磁共振成像中偶然观察到垂体肿块。组织学特征显示由肠道和结肠上皮形成的成熟畸胎瘤，随着Peyer斑块的形成而延伸的淋巴组织，和带有纤维囊的肌肉层痕迹。免疫组化显示对细胞角蛋白（CK）7，CKAE6/AE7，癌胚抗原，八聚体结合转录因子4,分化簇(CD)20,CD3,波形蛋白,肌肉肌动蛋白，和分离细胞中的垂体肿瘤转化基因1。然而,甲胎蛋白,β-人绒毛膜促性腺激素,人类胎盘催乳素，CK20，肿瘤抑制蛋白53和Kirsten大鼠肉瘤均为阴性。本文介绍了罕见鞍区肿块的临床和组织学特征以及治疗后的生存率。
