PDF(Pubmed)
Abstract：
Meningitis is a potential complication of elective intracranial surgery (EIS). The prevalence of meningitis after EIS varies greatly in the literature. The objective of this study was to estimate the overall pooled prevalence of meningitis following EIS. Four databases (PubMed, Scopus, Web of Science, and Embase) were searched to identify relevant studies. Meta-analyses of proportions were used to combine data. Cochran\'s Q and I2 statistics were used to assess and quantify heterogeneity. Additionally, several subgroup analyses were conducted to investigate the source of heterogeneity and examine differences in the prevalence based on variables such as geographical regions, income level, and meningitis type. The meta-analysis included 83 studies (30 959 patients) from 26 countries. The overall pooled prevalence of meningitis after EIS was 1.6% (95% CI 1.1-2.1), with high heterogeneity present (I2 = 88%). The pooled prevalence in low- to middle-income countries and high-income countries was 2.7% (95% CI 1.6-4.1) and 1.2% (95% CI 0.8-1.7), respectively. Studies that reported only aseptic meningitis had a pooled prevalence of 3.2% (95% CI 1.3-5.8). The pooled prevalence was 2.8% (95% CI 1.5-4.5) in studies that reported only bacterial meningitis. Similar prevalence rates of meningitis were observed in the subgroups of tumor resection, microvascular decompression, and aneurysm clipping. Meningitis is a rare but not exceptional complication following EIS, with an estimated prevalence of 1.6%.
摘要：
脑膜炎是选择性颅内手术（EIS）的潜在并发症。文献中EIS后脑膜炎的患病率差异很大。这项研究的目的是估计EIS后脑膜炎的总体汇总患病率。四个数据库(PubMed，Scopus,WebofScience,和Embase)进行搜索以确定相关研究。使用比例的荟萃分析来组合数据。Cochran的Q和I2统计量用于评估和量化异质性。此外,进行了几个亚组分析，以调查异质性的来源，并根据诸如地理区域等变量检查患病率的差异，收入水平,和脑膜炎类型。荟萃分析包括来自26个国家的83项研究（30959名患者）。EIS后脑膜炎的总体合并患病率为1.6％（95％CI1.1-2.1），存在高度异质性(I2=88%)。中低收入国家和高收入国家的合并患病率分别为2.7%(95%CI1.6-4.1)和1.2%(95%CI0.8-1.7)。分别。仅报告无菌性脑膜炎的研究合并患病率为3.2%（95%CI1.3-5.8）。在仅报道细菌性脑膜炎的研究中，合并患病率为2.8％（95％CI1.5-4.5）。在肿瘤切除的亚组中观察到相似的脑膜炎患病率，微血管减压术,动脉瘤夹闭.脑膜炎是EIS后一种罕见但并非异常的并发症，估计患病率为1.6%。
