PDF(Pubmed)
Abstract：
The endometrium is a highly dynamic tissue that undergoes dramatic proliferation and differentiation monthly in order to prepare the uterus for implantation and pregnancy. Intrauterine infection and inflammation are being increasingly recognized as potential causes of implantation failure and miscarriage, as well as obstetric complications later in gestation. However, the mechanisms by which the cells of the endometrium respond to infection remain understudied and recent progress is slowed in part owing to similar overlapping studies being performed in different species.
The aim of this scoping review is to systematically summarize all published studies in humans and laboratory animals that have investigated the innate immune sensing and response of the endometrium to bacteria and viruses, and the signaling mechanisms involved. This will enable gaps in our knowledge to be identified to inform future studies.
The Cochrane Library, Ovid Embase/Medline, PubMed, Scopus, Google Scholar, and Web of Science databases were searched using a combination of controlled and free text terms for uterus/endometrium, infections, and fertility to March 2022. All primary research papers that have reported on endometrial responses to bacterial and viral infections in the context of reproduction were included. To focus the scope of the current review, studies in domesticated animals, included bovine, porcine, caprine, feline, and canine species were excluded.
This search identified 42 728 studies for screening and 766 full-text studies were assessed for eligibility. Data was extracted from 76 studies. The majority of studies focused on endometrial responses to Escherichia coli and Chlamydia trachomatis, with some studies of Neisseria gonorrhea, Staphylococcus aureus, and the Streptococcus family. Endometrial responses have only been studied in response to three groups of viruses thus far: HIV, Zika virus, and the herpesvirus family. For most infections, both cellular and animal models have been utilized in vitro and in vivo, focusing on endometrial production of cytokines, chemokines, and antiviral/antimicrobial factors, and the expression of innate immune signaling pathway mediators after infection. This review has identified gaps for future research in the field as well as highlighted some recent developments in organoid systems and immune cell co-cultures that offer new avenues for studying endometrial responses to infection in more physiologically relevant models that could accelerate future findings in this area.
This scoping review provides an overarching summary and benchmark of the current state of research on endometrial innate immune responses to bacterial and viral infection. This review also highlights some exciting recent developments that enable future studies to be designed to deepen our understanding of the mechanisms utilized by the endometrium to respond to infection and their downstream effects on uterine function.
The aim of this scoping review is to systematically summarize all published studies in humans and laboratory animals that have investigated the innate immune sensing and response of the endometrium to bacteria and viruses, and the signaling mechanisms involved. This will enable gaps in our knowledge to be identified to inform future studies.
The Cochrane Library, Ovid Embase/Medline, PubMed, Scopus, Google Scholar, and Web of Science databases were searched using a combination of controlled and free text terms for uterus/endometrium, infections, and fertility to March 2022. All primary research papers that have reported on endometrial responses to bacterial and viral infections in the context of reproduction were included. To focus the scope of the current review, studies in domesticated animals, included bovine, porcine, caprine, feline, and canine species were excluded.
This search identified 42 728 studies for screening and 766 full-text studies were assessed for eligibility. Data was extracted from 76 studies. The majority of studies focused on endometrial responses to Escherichia coli and Chlamydia trachomatis, with some studies of Neisseria gonorrhea, Staphylococcus aureus, and the Streptococcus family. Endometrial responses have only been studied in response to three groups of viruses thus far: HIV, Zika virus, and the herpesvirus family. For most infections, both cellular and animal models have been utilized in vitro and in vivo, focusing on endometrial production of cytokines, chemokines, and antiviral/antimicrobial factors, and the expression of innate immune signaling pathway mediators after infection. This review has identified gaps for future research in the field as well as highlighted some recent developments in organoid systems and immune cell co-cultures that offer new avenues for studying endometrial responses to infection in more physiologically relevant models that could accelerate future findings in this area.
This scoping review provides an overarching summary and benchmark of the current state of research on endometrial innate immune responses to bacterial and viral infection. This review also highlights some exciting recent developments that enable future studies to be designed to deepen our understanding of the mechanisms utilized by the endometrium to respond to infection and their downstream effects on uterine function.
摘要：
背景：子宫内膜是一种高度动态的组织，每月经历急剧的增殖和分化，以便为子宫的植入和妊娠做好准备。宫内感染和炎症越来越被认为是植入失败和流产的潜在原因。以及妊娠后期的产科并发症。然而,子宫内膜细胞对感染的反应机制仍未得到充分研究,近期进展缓慢,部分原因是在不同物种中进行了类似的重叠研究.
目的：本范围综述的目的是系统地总结所有已发表的人类和实验动物的研究，这些研究已经调查了子宫内膜对细菌和病毒的先天免疫感知和反应，以及所涉及的信号机制。这将使我们的知识差距，以确定为未来的研究。
方法：Cochrane图书馆，OvidEmbase/Medline,PubMed,Scopus,谷歌学者，和WebofScience数据库使用对照和自由文本术语的子宫/子宫内膜的组合进行搜索，感染,和生育率到2022年3月。所有主要研究论文报道了子宫内膜对生殖背景下细菌和病毒感染的反应。为了集中当前审查的范围，对驯养动物的研究，包括牛，猪,caprine,猫科动物,和犬类被排除在外。
结果：这项搜索确定了42.728项筛查研究，并评估了766项全文研究的合格性。数据来自76项研究。大多数研究集中在子宫内膜对大肠杆菌和沙眼衣原体的反应，一些关于淋病奈瑟菌的研究，金黄色葡萄球菌,和链球菌家族。迄今为止，仅研究了对三组病毒的子宫内膜反应：HIV，寨卡病毒,和疱疹病毒家族。对于大多数感染，细胞和动物模型都已在体外和体内使用，专注于子宫内膜细胞因子的产生，趋化因子,和抗病毒/抗菌因素，以及感染后天然免疫信号通路介质的表达。这篇综述已经确定了该领域未来研究的差距，并强调了类器官系统和免疫细胞共培养的一些最新进展，这些进展为在更生理相关的模型中研究子宫内膜对感染的反应提供了新的途径，可以加速该领域的未来发现。
结论：本范围综述提供了子宫内膜对细菌和病毒感染的先天免疫反应的研究现状的总体总结和基准。这篇综述还强调了一些令人兴奋的最新进展，这些进展使未来的研究能够加深我们对子宫内膜对感染的反应机制及其对子宫功能的下游影响的理解。
目的：本范围综述的目的是系统地总结所有已发表的人类和实验动物的研究，这些研究已经调查了子宫内膜对细菌和病毒的先天免疫感知和反应，以及所涉及的信号机制。这将使我们的知识差距，以确定为未来的研究。
方法：Cochrane图书馆，OvidEmbase/Medline,PubMed,Scopus,谷歌学者，和WebofScience数据库使用对照和自由文本术语的子宫/子宫内膜的组合进行搜索，感染,和生育率到2022年3月。所有主要研究论文报道了子宫内膜对生殖背景下细菌和病毒感染的反应。为了集中当前审查的范围，对驯养动物的研究，包括牛，猪,caprine,猫科动物,和犬类被排除在外。
结果：这项搜索确定了42.728项筛查研究，并评估了766项全文研究的合格性。数据来自76项研究。大多数研究集中在子宫内膜对大肠杆菌和沙眼衣原体的反应，一些关于淋病奈瑟菌的研究，金黄色葡萄球菌,和链球菌家族。迄今为止，仅研究了对三组病毒的子宫内膜反应：HIV，寨卡病毒,和疱疹病毒家族。对于大多数感染，细胞和动物模型都已在体外和体内使用，专注于子宫内膜细胞因子的产生，趋化因子,和抗病毒/抗菌因素，以及感染后天然免疫信号通路介质的表达。这篇综述已经确定了该领域未来研究的差距，并强调了类器官系统和免疫细胞共培养的一些最新进展，这些进展为在更生理相关的模型中研究子宫内膜对感染的反应提供了新的途径，可以加速该领域的未来发现。
结论：本范围综述提供了子宫内膜对细菌和病毒感染的先天免疫反应的研究现状的总体总结和基准。这篇综述还强调了一些令人兴奋的最新进展，这些进展使未来的研究能够加深我们对子宫内膜对感染的反应机制及其对子宫功能的下游影响的理解。
