PDF(Pubmed)
Abstract：
Gray zone lymphoma is a very rare liquid malignancy that possesses intersecting features between primary mediastinal B-cell lymphoma and classic Hodgkin Lymphoma. In the case presented and accompanying literature review, we will discuss a patient with a chief complaint of shortness of breath and was found to have a mediastinal mass with biopsy consistent with mediastinal gray zone lymphoma. Herein, we explore the historical and recently updated diagnostic criteria of gray zone lymphoma from 2022 as well as the pathophysiology as it pertains to gene expression, while also reviewing the histological findings, epidemiology and treatment modalities.
摘要：
灰色区淋巴瘤是一种非常罕见的液体恶性肿瘤，具有原发性纵隔B细胞淋巴瘤和经典霍奇金淋巴瘤之间的交叉特征。在介绍的案例和随附的文献综述中，我们将讨论一名主诉为呼吸急促的患者，并被发现有纵隔肿块，活检与纵隔灰色区淋巴瘤一致。在这里，我们探讨了自2022年以来灰色地带淋巴瘤的历史和最近更新的诊断标准，以及与基因表达有关的病理生理学，同时回顾组织学发现，流行病学和治疗方式。
