PDF(Pubmed)
Abstract：
BACKGROUND: Recent evidence shows that COVID-19 infection does not have a worse prognosis in patients with immune-mediated inflammatory diseases (IMID), although they develop a worse response to vaccination.
OBJECTIVE: To compare the incidence of COVID-19 and clinical features in patients with IMID between the first and sixth waves.
METHODS: Prospective observational study of two cohorts of IMID patients diagnosed with COVID-19. First cohort March to May 2020, and second cohort December/2021 to February/2022. Sociodemographic and clinical variables were collected and, in the second cohort, COVID-19 vaccination status. Statistical analysis established differences in characteristics and clinical course between the two cohorts.
RESULTS: In total, 1627 patients were followed up, of whom 77 (4.60%) contracted COVID-19 during the first wave and 184 in the sixth wave (11.3%). In the sixth wave, there were fewer hospitalisations, intensive care unit admissions, and deaths than in the first wave (p=.000) and 180 patients (97.8%) had at least one dose of vaccine.
CONCLUSIONS: Early detection and vaccination have prevented the occurrence of serious complications.
OBJECTIVE: To compare the incidence of COVID-19 and clinical features in patients with IMID between the first and sixth waves.
METHODS: Prospective observational study of two cohorts of IMID patients diagnosed with COVID-19. First cohort March to May 2020, and second cohort December/2021 to February/2022. Sociodemographic and clinical variables were collected and, in the second cohort, COVID-19 vaccination status. Statistical analysis established differences in characteristics and clinical course between the two cohorts.
RESULTS: In total, 1627 patients were followed up, of whom 77 (4.60%) contracted COVID-19 during the first wave and 184 in the sixth wave (11.3%). In the sixth wave, there were fewer hospitalisations, intensive care unit admissions, and deaths than in the first wave (p=.000) and 180 patients (97.8%) had at least one dose of vaccine.
CONCLUSIONS: Early detection and vaccination have prevented the occurrence of serious complications.
摘要：
背景：最近的证据表明，在免疫介导的炎性疾病（IMID）患者中，COVID-19感染的预后并不差，尽管他们对疫苗接种的反应较差。
目的：比较第一波和第六波IMID患者COVID-19的发生率和临床特征。
方法：对两组诊断为COVID-19的IMID患者进行前瞻性观察性研究。第一组2020年3月至5月，第二组2021年12月至2022年2月。收集社会人口统计学和临床变量，在第二组中，COVID-19疫苗接种情况。统计分析确定了两个队列之间特征和临床过程的差异。
结果：总计，对1627例患者进行了随访，其中77人（4.60%）在第一波中感染了COVID-19，在第六波中感染了184人（11.3%）。在第六波浪潮中，住院人数较少，重症监护室入院，和死亡人数比第一波（p=.000）和180名患者（97.8％）至少接种了一剂疫苗。
结论：早期发现和接种疫苗可预防严重并发症的发生。
目的：比较第一波和第六波IMID患者COVID-19的发生率和临床特征。
方法：对两组诊断为COVID-19的IMID患者进行前瞻性观察性研究。第一组2020年3月至5月，第二组2021年12月至2022年2月。收集社会人口统计学和临床变量，在第二组中，COVID-19疫苗接种情况。统计分析确定了两个队列之间特征和临床过程的差异。
结果：总计，对1627例患者进行了随访，其中77人（4.60%）在第一波中感染了COVID-19，在第六波中感染了184人（11.3%）。在第六波浪潮中，住院人数较少，重症监护室入院，和死亡人数比第一波（p=.000）和180名患者（97.8％）至少接种了一剂疫苗。
结论：早期发现和接种疫苗可预防严重并发症的发生。
