OBJECTIVE: To compare the incidence of COVID-19 and clinical features in patients with IMID between the first and sixth waves.
METHODS: Prospective observational study of two cohorts of IMID patients diagnosed with COVID-19. First cohort March to May 2020, and second cohort December/2021 to February/2022. Sociodemographic and clinical variables were collected and, in the second cohort, COVID-19 vaccination status. Statistical analysis established differences in characteristics and clinical course between the two cohorts.
RESULTS: In total, 1627 patients were followed up, of whom 77 (4.60%) contracted COVID-19 during the first wave and 184 in the sixth wave (11.3%). In the sixth wave, there were fewer hospitalisations, intensive care unit admissions, and deaths than in the first wave (p=.000) and 180 patients (97.8%) had at least one dose of vaccine.
CONCLUSIONS: Early detection and vaccination have prevented the occurrence of serious complications.
目的:比较第一波和第六波IMID患者COVID-19的发生率和临床特征。
方法:对两组诊断为COVID-19的IMID患者进行前瞻性观察性研究。第一组2020年3月至5月,第二组2021年12月至2022年2月。收集社会人口统计学和临床变量,在第二组中,COVID-19疫苗接种情况。统计分析确定了两个队列之间特征和临床过程的差异。
结果:总计,对1627例患者进行了随访,其中77人(4.60%)在第一波中感染了COVID-19,在第六波中感染了184人(11.3%)。在第六波浪潮中,住院人数较少,重症监护室入院,和死亡人数比第一波(p=.000)和180名患者(97.8%)至少接种了一剂疫苗。
结论:早期发现和接种疫苗可预防严重并发症的发生。