Abstract：
MINCR (MYC-Induced Long Non-Coding RNA) is classified as an lncRNA. It has a significant correlation with MYC gene. MINCR has important roles in the carcinogenesis. It has been approved that this lncRNA can act as molecular sponge for miR-28-5p, miR-708-5p, miR-876-5p and miR-146a-5p. Dysregulated levels of MINCR has been observed in different types of cancer, especially hepatocellular carcinoma. In addition to malignant conditions, schizophrenia and neurodegenerative diseases such as Alzheimer\'s disease and amyotrophic lateral sclerosis are associated with dysregulation of expression patterns of MINCR. This review outlines MINCR molecular mechanisms of action in different disorders.
摘要：
MINCR(MYC诱导的长链非编码RNA)被分类为lncRNA。与MYC基因有显著的相干性。MINCR在癌变过程中具有重要作用。已经批准这种lncRNA可以作为miR-28-5p的分子海绵，miR-708-5p,miR-876-5p和miR-146a-5p。在不同类型的癌症中观察到MINCR水平失调，尤其是肝细胞癌。除了恶性疾病，精神分裂症和神经退行性疾病如阿尔茨海默病和肌萎缩侧索硬化症与MINCR表达模式失调有关。本文概述了MINCR在不同疾病中的分子作用机制。
