PDF(Pubmed)
Abstract：
Integra® Dermal Regeneration Template (IDRT, Integra LifeSciences, Princeton, NJ, USA) is a bilayer membrane developed, by Yannas and Burke in the 1980s, to fulfill the unmet need of surgeons having a readily available off-the-shelf dermal regeneration method. IDRT is composed of a sheet of porous cross-linked type I collagen and glycosaminoglycans, with a semi-permeable silicone sheet cover. IDRT is bio-engineered, from adult bovine Achilles tendons and chondroitin-6-sulfate derived from shark cartilage, in a multi-step process involving cross-linking using glutaraldehyde. By design, the composition, porosity, and biodegradation rate of IDRT guides the mechanism of wound repair towards a regenerative pathway. Its mechanism of action involves four distinct phases: imbibition, fibroblast migration, neovascularization, and remodeling/maturation. Originally developed for the post-excisional treatment of deep-partial to full-thickness burns where autograft is limited, over the years its use has expanded to reconstructive surgery.
摘要：
Integra®真皮再生模板(IDRT,IntegraLifeSciences,普林斯顿,NJ,美国)是一种双层膜，雅纳斯和伯克在20世纪80年代，以满足外科医生拥有现成的真皮再生方法的未满足的需求。IDRT由一层多孔交联的I型胶原蛋白和糖胺聚糖组成，用半渗透硅胶片覆盖。IDRT是生物工程的，来自成年牛跟腱和鲨鱼软骨的硫酸软骨素，在涉及使用戊二醛交联的多步骤过程中。根据设计，组成,孔隙度,IDRT的生物降解速率指导伤口修复的机制朝着再生途径发展。它的作用机制涉及四个不同的阶段：渗吸，成纤维细胞迁移,新生血管形成,和重塑/成熟。最初是为自体移植物有限的深部分至全厚度烧伤的切除后治疗而开发的，多年来，它的使用已扩展到重建手术。
