PDF(Pubmed)
Abstract：
UNASSIGNED: Japanese spotted fever (JSF) is a rare disease, caused by Rickettsia japonica; no case has been reported in Zhejiang Province, China.
UNASSIGNED: An elderly woman presented to the hospital with abdominal pain and fever. Her condition rapidly worsened with severe complications, such as multiple organ failure and central nervous system damage. The presence of R. japonica was quickly detected by metagenomic next-generation sequencing. On the basis of combined clinical manifestations and laboratory results, critical JSF was diagnosed and treated with doxycycline. The patient showed good prognosis. Typical symptoms (eschar and rash) were not observed in the early stage, consequently increasing the difficulty of clinical diagnosis.
UNASSIGNED: The delay of treatment caused by non-specific symptoms is an important factor affecting the progression of JSF. As an emerging pathogen detection method, mNGS has been successfully applied for disease diagnosis and treatment, and can be an important complement for the diagnosis of this disease.
UNASSIGNED: An elderly woman presented to the hospital with abdominal pain and fever. Her condition rapidly worsened with severe complications, such as multiple organ failure and central nervous system damage. The presence of R. japonica was quickly detected by metagenomic next-generation sequencing. On the basis of combined clinical manifestations and laboratory results, critical JSF was diagnosed and treated with doxycycline. The patient showed good prognosis. Typical symptoms (eschar and rash) were not observed in the early stage, consequently increasing the difficulty of clinical diagnosis.
UNASSIGNED: The delay of treatment caused by non-specific symptoms is an important factor affecting the progression of JSF. As an emerging pathogen detection method, mNGS has been successfully applied for disease diagnosis and treatment, and can be an important complement for the diagnosis of this disease.
摘要：
■日本斑疹热（JSF）是一种罕见的疾病，由日本立克次体引起；浙江省没有病例报告，中国。
■一位老年妇女因腹痛和发烧被送到医院。她的病情迅速恶化并出现严重并发症,如多器官功能衰竭和中枢神经系统损害。通过宏基因组下一代测序可以快速检测到粳稻的存在。结合临床表现和实验室检查结果,危重的JSF被诊断并接受多西环素治疗。患者预后良好。早期未观察到典型症状（焦痂和皮疹），增加了临床诊断的难度。
■由非特异性症状引起的治疗延迟是影响JSF进展的重要因素。作为一种新兴的病原体检测方法,mNGS已成功应用于疾病诊断和治疗，可以作为诊断这种疾病的重要补充。
■一位老年妇女因腹痛和发烧被送到医院。她的病情迅速恶化并出现严重并发症,如多器官功能衰竭和中枢神经系统损害。通过宏基因组下一代测序可以快速检测到粳稻的存在。结合临床表现和实验室检查结果,危重的JSF被诊断并接受多西环素治疗。患者预后良好。早期未观察到典型症状（焦痂和皮疹），增加了临床诊断的难度。
■由非特异性症状引起的治疗延迟是影响JSF进展的重要因素。作为一种新兴的病原体检测方法,mNGS已成功应用于疾病诊断和治疗，可以作为诊断这种疾病的重要补充。
