PDF(Pubmed)
Abstract：
Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.
摘要：
猛禽,mTORC1的关键成分是向mTORC1募集底物并有助于其亚细胞定位所必需的。Raptor具有高度保守的N端结构域和七个WD40重复序列，与mTOR和其他mTORC1相关蛋白相互作用。mTORC1参与各种细胞事件并介导分化和代谢。直接或间接地,许多因素介导淋巴细胞的分化和功能，这对免疫至关重要。在这次审查中,我们总结了Raptor在淋巴细胞分化和功能中的作用，Raptor介导细胞因子的分泌以诱导早期淋巴细胞代谢，发展,扩散和迁移。此外,Raptor通过调节淋巴细胞的稳态维持和激活来调节淋巴细胞的功能。
