PDF(Pubmed)
Abstract：
OBJECTIVE: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).
METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher\'s exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.
RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.
CONCLUSIONS: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.
METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher\'s exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.
RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.
CONCLUSIONS: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.
摘要：
目的：确定HLA-B27阳性对发生慢性非细菌性骨髓炎（CNO）风险的影响。
方法：在3个欧洲CNO人群中评估了HLA-B*27基因型，并与当地对照人群进行了比较（572例，33,256个控件）。在所有病例的诊断和随访中都进行了区域或全身MRI检查，这降低了疾病错误分类的风险。使用下一代DNA测序或基于PCR的分子分型进行基因分型。统计分析使用Fisher精确检验和Bonferroni校正和固定效应模型进行比值比的荟萃分析。
结果：HLA-B*27在所有3个人群中的频率均高于局部对照组（组合比值比（OR）=2.2，p值=3×10-11）。与女性病例相比，男性病例的这种相关性更强（OR=1.99，校正后的p值=0.015）。然而,HLA-B*27状态与银屑病的共同发生无统计学意义，关节炎或炎症性肠病。
结论：携带HLA-B*27与发生CNO的更大风险相关，尤其是男性。
方法：在3个欧洲CNO人群中评估了HLA-B*27基因型，并与当地对照人群进行了比较（572例，33,256个控件）。在所有病例的诊断和随访中都进行了区域或全身MRI检查，这降低了疾病错误分类的风险。使用下一代DNA测序或基于PCR的分子分型进行基因分型。统计分析使用Fisher精确检验和Bonferroni校正和固定效应模型进行比值比的荟萃分析。
结果：HLA-B*27在所有3个人群中的频率均高于局部对照组（组合比值比（OR）=2.2，p值=3×10-11）。与女性病例相比，男性病例的这种相关性更强（OR=1.99，校正后的p值=0.015）。然而,HLA-B*27状态与银屑病的共同发生无统计学意义，关节炎或炎症性肠病。
结论：携带HLA-B*27与发生CNO的更大风险相关，尤其是男性。
