PDF(Pubmed)
Abstract：
Metabolite-based T-cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, and cancer. Here, small-molecule metabolites were identified to be captured and presented by the major histocompatibility complex class-I-related molecule (MR1) to T cells, namely mucosal-associated invariant T cells (MAIT) and diverse MR1-restricted T cells. Both MR1 and MAIT are evolutionarily conserved in many mammals, suggesting important roles in host immunity. Rational chemical modifications of these naturally occurring metabolites, termed altered metabolite ligands (AMLs), have advanced our understanding of the molecular correlates of MAIT T cell receptor (TCR)-MR1 recognition. This review provides a generalized framework for metabolite recognition and modulation of MAIT cells.
摘要：
基于代谢物的T细胞免疫正在成为抗菌免疫的主要参与者，自身免疫,和癌症。这里,小分子代谢物被鉴定为被捕获并由主要组织相容性复合物I类相关分子（MR1）呈递至T细胞，即粘膜相关不变T细胞（MAIT）和多种MR1限制性T细胞。MR1和MAIT在许多哺乳动物中都是进化保守的，提示在宿主免疫中的重要作用。对这些天然存在的代谢物进行合理的化学修饰，称为改变的代谢物配体（AMLs），提高了我们对MAITT细胞受体（TCR）-MR1识别的分子相关性的理解。这篇综述为MAIT细胞的代谢物识别和调节提供了一个通用框架。
