OBJECTIVE: We aimed to systematically review the literature concerned with the associations between heart rate variability (HRV), as an ANS biomarker, and pregnancy complications.
METHODS: We performed a comprehensive search in the PubMed, Medline Completion, CINAHL Completion, Web of Science Core Collection Classic, Cochrane Library, and SCOPUS databases in February 2022 with no time span limitation. We included studies concerned with the association between any pregnancy complications and HRV, with or without a control group. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline was used for the review of the studies, and Covidence software was used for the study selection process. For data synthesis, we used the guideline by Popay et al.
RESULTS: Finally, 12 studies with 6656 participants were included. Despite the methodological divergency that hindered a comprehensive comparison, our findings suggest that ANS is linked with some common pregnancy complications including fetal growth. However, existing studies do not support an association between ANS and gestational diabetes mellitus. Studies that linked pulmonary and central nervous system disorders with ANS function did not provide enough evidence to draw conclusions.
CONCLUSIONS: This review highlights the importance of understanding and monitoring the underlying mechanism of ANS in pregnancy-induced adaptations and the need for further research with robust methodology in this area.
目的:我们旨在系统地回顾与心率变异性(HRV),作为ANS生物标志物,妊娠并发症。
方法:我们在PubMed中进行了全面的搜索,Medline完成,CINAHL完成,WebofScience核心合集经典,科克伦图书馆,和SCOPUS数据库于2022年2月发布,没有时间跨度限制。我们纳入了有关任何妊娠并发症与HRV之间关联的研究,有或没有对照组。PRISMA(系统评价和荟萃分析的首选报告项目)指南用于审查研究,并使用Covidence软件进行研究选择。对于数据合成,我们使用了Popay等人的指导方针。
结果:最后,纳入了12项研究,有6656名参与者。尽管方法上的分歧阻碍了全面比较,我们的研究结果表明,ANS与一些常见的妊娠并发症有关,包括胎儿生长.然而,现有研究不支持ANS与妊娠期糖尿病之间的关联.将肺和中枢神经系统疾病与ANS功能联系起来的研究没有提供足够的证据来得出结论。
结论:这篇综述强调了理解和监测ANS在妊娠诱导的适应中的潜在机制的重要性,以及在这一领域需要用强有力的方法学进行进一步研究。