PDF(Pubmed)
Abstract：
UNASSIGNED: Whether cardiovascular health (CVH) metrics impact longevity with and without cardiovascular diseases (CVDs) has not been well established. This study aimed to investigate the association between CVH metrics and life expectancy in participants free of CVD events. We hypothesized that ideal CVH status was associated with increased life expectancy and assessed the effect of CVH status as a prevention target of longevity in the framework of predictive, preventive, and personalized medicine (PPPM/3PM).
UNASSIGNED: A total of 92,795 participants in the Kailuan study were examined and thereafter followed up until 2020. We considered three transitions (from non-CVD events to incident CVD events, from non-CVD events to mortality, and from CVD events to mortality). The multistate lifetable method was applied to estimate the life expectancy.
UNASSIGNED: During a median follow-up of 13 years, 12,541 (13.51%) deaths occurred. Compared with poor CVH, ideal CVH attenuated the risk of incident CVD events and mortality without CVD events by approximately 58% and 27%, respectively. Women with ideal CVH at age 35 had a 5.00 (3.23-6.77) year longer life expectancy free of CVD events than did women with poor CVH metrics. Among men, ideal CVH was associated with a 6.74 (5.55-7.93) year longer life expectancy free of CVD events.
UNASSIGNED: An ideal CVH status is associated with a lower risk of premature mortality and a longer life expectancy, either in the general population or in CVD patients, which are cost-effective ways for personalized medicine of potential CVD patients. Our findings suggest that the promotion of a higher CVH score or ideal CVH status would result in reduced burdens of CVD events and extended disease-free life expectancy, which offered an accurate prediction for primary care following the concept of PPPM/3PM.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13167-023-00322-8.
UNASSIGNED: A total of 92,795 participants in the Kailuan study were examined and thereafter followed up until 2020. We considered three transitions (from non-CVD events to incident CVD events, from non-CVD events to mortality, and from CVD events to mortality). The multistate lifetable method was applied to estimate the life expectancy.
UNASSIGNED: During a median follow-up of 13 years, 12,541 (13.51%) deaths occurred. Compared with poor CVH, ideal CVH attenuated the risk of incident CVD events and mortality without CVD events by approximately 58% and 27%, respectively. Women with ideal CVH at age 35 had a 5.00 (3.23-6.77) year longer life expectancy free of CVD events than did women with poor CVH metrics. Among men, ideal CVH was associated with a 6.74 (5.55-7.93) year longer life expectancy free of CVD events.
UNASSIGNED: An ideal CVH status is associated with a lower risk of premature mortality and a longer life expectancy, either in the general population or in CVD patients, which are cost-effective ways for personalized medicine of potential CVD patients. Our findings suggest that the promotion of a higher CVH score or ideal CVH status would result in reduced burdens of CVD events and extended disease-free life expectancy, which offered an accurate prediction for primary care following the concept of PPPM/3PM.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13167-023-00322-8.
摘要：
■心血管健康（CVH）指标是否影响有或没有心血管疾病（CVDs）的寿命尚未得到很好的确定。本研究旨在调查无CVD事件参与者的CVH指标与预期寿命之间的关系。我们假设理想的CVH状态与预期寿命增加有关，并在预测框架内评估CVH状态作为长寿预防目标的效果，预防性,和个性化医疗（PPPM/3PM）。
■共有92,795名在开uan研究中的参与者接受了检查，然后随访到2020年。我们考虑了三个转变（从非CVD事件到偶发CVD事件，从非CVD事件到死亡率，从CVD事件到死亡率)。多状态寿命方法用于估计预期寿命。
■在13年的中位随访期间，12,541例（13.51%）死亡。与差的CVH相比，理想的CVH将CVD事件的发生率和无CVD事件的死亡率降低了约58%和27%,分别。与CVH指标较差的女性相比，在35岁时具有理想CVH的女性，无CVD事件的预期寿命延长了5.00（3.23-6.77）年。在男性中,理想的CVH与预期寿命延长6.74(5.55~7.93)年无CVD事件相关.
■理想的CVH状态与较低的过早死亡风险和较长的预期寿命相关，无论是普通人群还是心血管疾病患者，这是潜在的心血管疾病患者个性化医疗的经济有效的方法。我们的研究结果表明，促进更高的CVH评分或理想的CVH状态将导致减少CVD事件的负担和延长无病预期寿命。这为遵循PPPM/3PM概念的初级保健提供了准确的预测。
■在线版本包含补充材料，可在10.1007/s13167-023-00322-8获得。
■共有92,795名在开uan研究中的参与者接受了检查，然后随访到2020年。我们考虑了三个转变（从非CVD事件到偶发CVD事件，从非CVD事件到死亡率，从CVD事件到死亡率)。多状态寿命方法用于估计预期寿命。
■在13年的中位随访期间，12,541例（13.51%）死亡。与差的CVH相比，理想的CVH将CVD事件的发生率和无CVD事件的死亡率降低了约58%和27%,分别。与CVH指标较差的女性相比，在35岁时具有理想CVH的女性，无CVD事件的预期寿命延长了5.00（3.23-6.77）年。在男性中,理想的CVH与预期寿命延长6.74(5.55~7.93)年无CVD事件相关.
■理想的CVH状态与较低的过早死亡风险和较长的预期寿命相关，无论是普通人群还是心血管疾病患者，这是潜在的心血管疾病患者个性化医疗的经济有效的方法。我们的研究结果表明，促进更高的CVH评分或理想的CVH状态将导致减少CVD事件的负担和延长无病预期寿命。这为遵循PPPM/3PM概念的初级保健提供了准确的预测。
■在线版本包含补充材料，可在10.1007/s13167-023-00322-8获得。
