PDF(Pubmed)
Abstract：
This prospective, descriptive study focused on lung flukes (Hematoloechus sp., H) and their impact on systemic and individual capillary variables measured in pithed Rana pipiens, a long-standing model for studies of capillary physiology. Three groups were identified based on Hematoloechus attachment: no Hematoloechus (No H), Hematoloechus not attached (H Not Att), and Hematoloechus attached (H Att). Among 38 descriptive, cardiovascular, and immunological variables, 18 changed significantly with H. Symptoms of H included weight loss, elevated immune cells, heart rate variability, faster coagulation, lower hematocrit, and fluid accumulation. Important capillary function discoveries included median baselines for hydraulic conductivity (Lp) of 7.0 (No H), 12.4 (H Not Att), and 4.2 (H Att) × 10-7 cm·s-1·cmH2O-1 (P < 0.0001) plus seasonal adaptation of sigma delta pi [σ(πc-πi), P = 0.03]. Pro- and anti-inflammatory phases were revealed for Lp and plasma nitrite/nitrate concentration ([NOx]) in both H Not Att and H Att, whereas capillary wall tensile strength increased in the H Att. H attachment was advantageous for the host due to lower edema and for the parasite via a sustained food source illustrating an excellent example of natural symbiosis. However, H attachment also resulted in host weight loss: in time, a conundrum for the highly dependent parasite. The study increases overall knowledge of Rana pipiens by revealing intriguing effects of H and previously unknown, naturally occurring seasonal changes in many variables. The data improve Rana pipiens as a general scientific and capillary physiology model. Diseases of inflammation and stroke are among the clinical applications.
摘要：
这个未来,描述性研究侧重于肺吸虫(Haematoloechussp.,H)及其对pithedRanapipiens测量的全身和个体毛细血管变量的影响，一个长期的毛细血管生理学研究模型。根据H依恋确定了三组：无血球(无H)，Haematoloechusnotattached(HNotAtt),和附加的Haematoloechus（HAtt）。在38个描述性的，心血管,和免疫学变量，18随H的变化显着。H的症状包括体重减轻，免疫细胞升高，心率变异性,更快的凝血，降低血细胞比容,和液体积聚。重要的毛细管功能发现包括水力传导率（Lp）的中值基线为7.0（无H），12.4(HNotAtt)，和4.2（HAtt）x10-7厘米。s-1.cmH2O-1(P<0.0001)加上sigmadeltapi(s(pc-pi)，P=0.03)。HNotAtt和HAtt中的Lp和血浆亚硝酸盐/硝酸盐浓度（[NOx]）揭示了促炎和抗炎阶段，HAtt中的毛细管壁拉伸强度增加。由于较低的水肿，H附着对宿主有利，并且通过持续的食物来源对寄生虫有利，这是自然共生的一个很好的例子。然而,H依恋也导致宿主体重减轻：及时，一个高度依赖的寄生虫的难题。该研究通过揭示H和以前未知的有趣影响，增加了对象牙的整体了解。自然发生的许多变量的季节性变化。数据改善了Ranapipiens作为一般的科学和毛细血管生理学模型。炎症和中风疾病是临床应用之一。
