We retrieved records from Pubmed, Web of Science, Scopus, and Cochrane Library to identify studies published between January 2002 and October 2022.
Articles were independently assessed by 2 reviewers and verified by a third reviewer. Published cross-sectional studies, cohort/longitudinal studies, case series, and noncomparative cohort studies were considered eligible for inclusion. We conducted a systematic review and meta-analysis according to a registered protocol on the International Prospective Register of Systematic Reviews and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Selected studies were classified into 2 groups: epidemiological and genetic association studies. Relative frequencies and odds ratios (ORs) for each autoinflammatory/autoimmune disease or genetic marker reported to be associated with MD.
Fifteen studies from 6 countries met our inclusion criteria. Nine are epidemiological studies and 6 are genetic association studies. The epidemiological studies were used to perform 3 different meta-analyses. Airway allergic disease and autoimmune thyroid disease showed a significant association with MD (OR = 2.27 [2.08-2.48] and OR = 1.35 [1.25-1.46]); while rheumatoid arthritis did not (OR = 0.63 [0.28-1.41]). Other comorbidities also showed a significant association with MD like chronic obstructive pulmonary disease, vitiligo, fibromyalgia, arthritis, and psoriasis.
Epidemiological evidence supports an association between MD and immune-related disorders in European and Asian populations, with population-specific effects. The evaluation of thyroid diseases, airway allergic diseases, and other inflammatory diseases should be implemented in the clinical management of MD patients.
方法:我们从Pubmed,WebofScience,Scopus,和Cochrane图书馆确定2022年1月至10月发表的研究。
方法:文章由两名评审员独立评估,并由第三名评审员验证。发表的横断面研究,队列/纵向研究,案例系列,非比较性队列研究被认为符合纳入条件.我们根据系统评价和荟萃分析指南的国际前瞻性系统评价和首选报告项目注册协议进行了系统评价和荟萃分析。选定的研究分为两组:流行病学和遗传关联研究。每种自身炎症/自身免疫性疾病或遗传标记的相对频率和比值比(ORs)被报道与MD相关。
结果:来自6个国家的15项研究符合我们的纳入标准。九项是流行病学研究,六项是遗传关联研究。流行病学研究用于进行3种不同的荟萃分析。气道过敏性疾病和自身免疫性甲状腺疾病与MD显著相关(OR=2.27[2.08-2.48]和OR=1.35[1.25-1.46]);而类风湿性关节炎则没有相关性(OR=0.63[0.28-1.41])。其他合并症也显示出与MD如慢性阻塞性肺疾病显著相关,白癜风,纤维肌痛,关节炎,牛皮癣。
结论:流行病学证据支持欧洲和亚洲人群中MD和免疫相关疾病之间的关联。具有特定人群的影响。甲状腺疾病的评估,气道过敏性疾病,和其他炎症性疾病应在MD患者的临床管理中实施。