Abstract：
Long-coronavirus disease (COVID) is an ill-defined set of symptoms persisting in patients following infection with COVID-19 that range from any combination of persistent breathing difficulties to anosmia, impaired attention, memory, fatigue, or pain. Recently, noninvasive transcutaneous electrical brain stimulation techniques have been showing early signs of success in addressing some of these complaints. We postulate that the use of a stimulation technique with transcranial magnetic stimulation may also similarly be effective. A 36-year-old male suffering from symptoms of dyspnea, anosmia, and \"brain fog\" for 2 years following coronavirus infection was treated with 10 sessions of Electro-Magnetic Brain Pulse (EMBP®), a personalized transcranial magnetic stimulation protocol guided by the patient\'s electroencephalograph (EEG). At the conclusion of the treatment, the patient had improvements in mood, sense of smell, and brain fogging. Dyspnea also decreased with a gain of 11% forced expiratory volume 1/forced vital capacity. A high-sensitivity athletic training cognitive test showed an overall 27% increase in aggregate score. A significant portion of this was attributed to changes in visual clarity and decision-making speed. Post-treatment EEG showed a shift from predominantly delta waves to more synchronized alpha wave patterns during the resting state. Brain stimulation techniques appear to be showing early signs of success with long-COVID symptoms. This is the first case describing the use of a magnetic stimulation technique with quantitative test results and recorded EEG changes. Given the early success in this patient with cognition, dyspnea, and anosmia, this noninvasive treatment modality warrants further research.
摘要：
长冠状病毒病(COVID)是一组不明确的症状，在感染COVID-19后持续存在，从持续呼吸困难到失语症的任何组合，注意力受损，记忆,疲劳,或疼痛。最近,非侵入性经皮脑电刺激技术在解决其中一些投诉方面已显示出成功的早期迹象。我们推测，使用经颅磁刺激的刺激技术也可能同样有效。一名患有呼吸困难症状的36岁男性，嗅觉缺失,和“脑雾”在冠状病毒感染后2年接受了10次电磁脑脉冲（EMBP®）治疗，患者脑电图（EEG）指导下的个性化经颅磁刺激方案。治疗结束后，病人的情绪有了改善,嗅觉,和大脑雾化。呼吸困难也减少了，用力呼气量1/用力肺活量增加了11％。一项高灵敏度运动训练认知测试显示，总分总体提高了27%。其中很大一部分归因于视觉清晰度和决策速度的变化。在静息状态下，治疗后的EEG显示出从主要的δ波到更同步的α波模式的转变。脑刺激技术似乎显示出早期成功迹象，并伴有长期COVID症状。这是描述使用具有定量测试结果和记录的EEG变化的磁刺激技术的第一种情况。鉴于该患者在认知方面的早期成功，呼吸困难,和嗅觉缺失，这种无创治疗方式值得进一步研究。
