PDF(Pubmed)
Abstract：
UNASSIGNED: A short-term immobilization of one hand affects musculoskeletal functions, and the associated brain network adapts to the alterations happening to the body due to injuries. It was hypothesized that the injury-associated temporary disuse of the upper limb would alter the functional interactions of the motor cortical processes and will produce long-term changes throughout the immobilization and post-immobilization period.
UNASSIGNED: The case participant (male, 12 years old, right arm immobilized for clavicle fracture) was scanned using optical imaging technology of fNIRS over immobilization and post-immobilization. Pre-task data was collected for 3 min for RSFC analysis, processed, and analyzed using the Brain AnalyzIR toolbox. Connectivity was measured using Pearson correlation coefficients (R) from NIRS Toolbox\'s connectivity module.
UNASSIGNED: The non-affected hand task presented an increased ipsilateral response during the immobilization period, which then decreased over the follow-up visits. The right-hand task showed a bilateral activation pattern following immobilization, but the contralateral activation pattern was restored during the 1-year follow-up visit. Significant differences in the average connection strength over the study period were observed. The average Connection strength decreased from the third week of immobilization and continued to be lower than the baseline value. Global network efficiency decreased in weeks two and three, while the network settled into a higher efficient state during the follow-up periods after post-immobilization.
UNASSIGNED: Short-term immobilization of the upper limb is shown to have cortical changes in terms of activations of brain regions as well as connectivity. The short-term dis-use of the upper limb has shifted the unilateral activation pattern to the bilateral coactivation of the motor cortex from both hemispheres. Resting-state data reveals a disruption in the motor cortical network during the immobilization phase, and the network is reorganized into an efficient network over 1 year after the injury. Understanding such cortical reorganization could be informative for studying the recovery from neurological disorders affecting motor control in the future.
UNASSIGNED: The case participant (male, 12 years old, right arm immobilized for clavicle fracture) was scanned using optical imaging technology of fNIRS over immobilization and post-immobilization. Pre-task data was collected for 3 min for RSFC analysis, processed, and analyzed using the Brain AnalyzIR toolbox. Connectivity was measured using Pearson correlation coefficients (R) from NIRS Toolbox\'s connectivity module.
UNASSIGNED: The non-affected hand task presented an increased ipsilateral response during the immobilization period, which then decreased over the follow-up visits. The right-hand task showed a bilateral activation pattern following immobilization, but the contralateral activation pattern was restored during the 1-year follow-up visit. Significant differences in the average connection strength over the study period were observed. The average Connection strength decreased from the third week of immobilization and continued to be lower than the baseline value. Global network efficiency decreased in weeks two and three, while the network settled into a higher efficient state during the follow-up periods after post-immobilization.
UNASSIGNED: Short-term immobilization of the upper limb is shown to have cortical changes in terms of activations of brain regions as well as connectivity. The short-term dis-use of the upper limb has shifted the unilateral activation pattern to the bilateral coactivation of the motor cortex from both hemispheres. Resting-state data reveals a disruption in the motor cortical network during the immobilization phase, and the network is reorganized into an efficient network over 1 year after the injury. Understanding such cortical reorganization could be informative for studying the recovery from neurological disorders affecting motor control in the future.
摘要：
■一只手的短期固定会影响肌肉骨骼功能，和相关的大脑网络适应身体因受伤而发生的变化。据推测，与上肢损伤相关的暂时废用会改变运动皮层过程的功能相互作用，并在整个固定和固定后期间产生长期变化。
■病例参与者(男性，12岁,锁骨骨折固定的右臂）使用fNIRS的光学成像技术在固定和固定后进行扫描。任务前数据收集3分钟用于RSFC分析，已处理,并使用BrainAnalyzIR工具箱进行分析。使用来自NIRSToolbox的连通性模块的Pearson相关系数(R)测量连通性。
■未受影响的手部任务在固定期间表现出增加的同侧反应，然后在后续访问中有所下降。右侧任务显示固定后的双侧激活模式，但在1年随访期间,对侧激活模式恢复.在研究期间观察到平均连接强度的显着差异。平均连接强度从固定的第三周开始下降，并继续低于基线值。全球网络效率在第二周和第三周下降，而在固定后的随访期间，网络进入了更高效的状态。
■显示上肢的短期固定在脑区的激活和连通性方面具有皮质变化。上肢的短期使用已将单侧激活模式从两个半球转移到运动皮层的双侧共激活。静息状态数据揭示了在固定阶段运动皮层网络的中断，在受伤后的1年内，网络被重组为一个高效的网络。了解这种皮质重组可以为将来研究影响运动控制的神经系统疾病的恢复提供信息。
■病例参与者(男性，12岁,锁骨骨折固定的右臂）使用fNIRS的光学成像技术在固定和固定后进行扫描。任务前数据收集3分钟用于RSFC分析，已处理,并使用BrainAnalyzIR工具箱进行分析。使用来自NIRSToolbox的连通性模块的Pearson相关系数(R)测量连通性。
■未受影响的手部任务在固定期间表现出增加的同侧反应，然后在后续访问中有所下降。右侧任务显示固定后的双侧激活模式，但在1年随访期间,对侧激活模式恢复.在研究期间观察到平均连接强度的显着差异。平均连接强度从固定的第三周开始下降，并继续低于基线值。全球网络效率在第二周和第三周下降，而在固定后的随访期间，网络进入了更高效的状态。
■显示上肢的短期固定在脑区的激活和连通性方面具有皮质变化。上肢的短期使用已将单侧激活模式从两个半球转移到运动皮层的双侧共激活。静息状态数据揭示了在固定阶段运动皮层网络的中断，在受伤后的1年内，网络被重组为一个高效的网络。了解这种皮质重组可以为将来研究影响运动控制的神经系统疾病的恢复提供信息。
