Abstract：
The 730 nm picosecond titanium sapphire laser is a novel laser that shows promising results in treating freckles. This study aimed to further investigate the efficacy and safety of the 730 nm picosecond titanium sapphire laser for treating freckles in Asian patients compared with those of the 755 nm picosecond alexandrite laser.
Each face of 86 participants was split into two parts and randomly assigned either one session of 730 or 755 nm picosecond-laser treatment each. Efficacy and safety were determined based on blinded visual evaluations and self-reports at each follow-up visit.
The treatment outcomes of the 730 nm picosecond laser for the treatment of freckles were comparable to those of the 755 nm picosecond laser, with 68.99 ± 7.42% and 69.27 ± 7.75% clearance, respectively (p > 0.05). Participants achieved similar Global Aesthetic Improvement Scale scores (4.04 ± 0.31 vs. 4.02 ± 0.30, respectively [p > 0.05]). Additionally, the 730 nm picosecond laser was perceived to be less painful than the 755 nm picosecond laser (4.69 ± 1.63 vs. 5.65 ± 1.80 nm, p < 0.0001).
The 730 nm picosecond laser is safe and effective for the treatment of freckles in Asian patients. Besides, the 730 nm picosecond laser is less painful than the 755 nm picosecond laser.
Each face of 86 participants was split into two parts and randomly assigned either one session of 730 or 755 nm picosecond-laser treatment each. Efficacy and safety were determined based on blinded visual evaluations and self-reports at each follow-up visit.
The treatment outcomes of the 730 nm picosecond laser for the treatment of freckles were comparable to those of the 755 nm picosecond laser, with 68.99 ± 7.42% and 69.27 ± 7.75% clearance, respectively (p > 0.05). Participants achieved similar Global Aesthetic Improvement Scale scores (4.04 ± 0.31 vs. 4.02 ± 0.30, respectively [p > 0.05]). Additionally, the 730 nm picosecond laser was perceived to be less painful than the 755 nm picosecond laser (4.69 ± 1.63 vs. 5.65 ± 1.80 nm, p < 0.0001).
The 730 nm picosecond laser is safe and effective for the treatment of freckles in Asian patients. Besides, the 730 nm picosecond laser is less painful than the 755 nm picosecond laser.
摘要：
目的：730nm皮秒钛蓝宝石激光器是一种新型激光器，在治疗雀斑方面显示出有希望的结果。本研究旨在进一步研究730nm皮秒钛蓝宝石激光治疗亚洲患者雀斑的疗效和安全性，与755nm皮秒宝石激光治疗相比。
方法：将86名参与者的每一张脸分成两部分，随机分配给每一张730或755nm皮秒激光治疗。在每次随访时基于盲目性视觉评估和自我报告来确定功效和安全性。
结果：730nm皮秒激光治疗雀斑的治疗结果与755nm皮秒激光治疗结果相当，具有68.99±7.42%和69.27±7.75%的清除率，分别为(p>0.05)。参与者获得了相似的全球美学改善量表评分（4.04±0.31vs.分别为4.02±0.30[p>0.05])。此外,730nm皮秒激光被认为比755nm皮秒激光疼痛小(4.69±1.63vs.5.65±1.80nm,p<0.0001)。
结论：730nm皮秒激光治疗亚洲患者的雀斑是安全有效的。此外,730nm皮秒激光比755nm皮秒激光疼痛小。
方法：将86名参与者的每一张脸分成两部分，随机分配给每一张730或755nm皮秒激光治疗。在每次随访时基于盲目性视觉评估和自我报告来确定功效和安全性。
结果：730nm皮秒激光治疗雀斑的治疗结果与755nm皮秒激光治疗结果相当，具有68.99±7.42%和69.27±7.75%的清除率，分别为(p>0.05)。参与者获得了相似的全球美学改善量表评分（4.04±0.31vs.分别为4.02±0.30[p>0.05])。此外,730nm皮秒激光被认为比755nm皮秒激光疼痛小(4.69±1.63vs.5.65±1.80nm,p<0.0001)。
结论：730nm皮秒激光治疗亚洲患者的雀斑是安全有效的。此外,730nm皮秒激光比755nm皮秒激光疼痛小。
