Abstract：
BACKGROUND: Alexithymia is a neuropsychiatric symptom conceptualized as difficulty identifying and describing feelings. Although associated with other non-motor symptoms, mainly neuropsychiatric, alexithymia may present as an isolated symptom in persons with Parkinson\'s Disease (PwP). The objective of the study is to identify determinants of alexithymia and its association with quality of life (QoL) in Parkinson\'s disease.
METHODS: Subjects with Parkinson\'s disease were recruited. The following instruments were applied: Movement Disorders Society Unified Parkinson\'s Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment (MoCA), Toronto alexithymia scale (TAS-20) and Parkinson\'s Disease Questionnaire (PDQ-8). Matched healthy controls were screened using TAS-20. Clinical and demographical variables were compared between alexithymic and non-alexithymic. Regression models were used to find determinants of alexithymia. Impact of alexithymia on QoL was estimated with a linear regression model.
RESULTS: 98 patients were included. 56.1% PwP and 28.8% controls were alexithymic (p<0.001). Education level (OR 0.86) and NMSS urinary score (OR 1.09) determined alexithymia as well as TAS-20 score. Alexithymia was an independent determinant of QoL.
CONCLUSIONS: Alexithymia is a prevalent independent non-motor symptom in PwP with impact on QoL. Low education level and urinary symptoms are important determinants of alexithymia.
METHODS: Subjects with Parkinson\'s disease were recruited. The following instruments were applied: Movement Disorders Society Unified Parkinson\'s Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment (MoCA), Toronto alexithymia scale (TAS-20) and Parkinson\'s Disease Questionnaire (PDQ-8). Matched healthy controls were screened using TAS-20. Clinical and demographical variables were compared between alexithymic and non-alexithymic. Regression models were used to find determinants of alexithymia. Impact of alexithymia on QoL was estimated with a linear regression model.
RESULTS: 98 patients were included. 56.1% PwP and 28.8% controls were alexithymic (p<0.001). Education level (OR 0.86) and NMSS urinary score (OR 1.09) determined alexithymia as well as TAS-20 score. Alexithymia was an independent determinant of QoL.
CONCLUSIONS: Alexithymia is a prevalent independent non-motor symptom in PwP with impact on QoL. Low education level and urinary symptoms are important determinants of alexithymia.
摘要：
背景：述情障碍是一种神经精神症状，被概念化为难以识别和描述感觉。尽管与其他非运动症状有关，主要是神经精神病学，述情障碍可能表现为帕金森病（PwP）患者的孤立症状。该研究的目的是确定帕金森病述情障碍的决定因素及其与生活质量(QoL)的关系。
方法：招募帕金森病患者。应用了以下工具：运动障碍协会统一帕金森病评定量表（MDS-UPDRS），非运动症状量表（NMSS），蒙特利尔认知评估（MoCA）多伦多述情障碍量表(TAS-20)和帕金森病问卷(PDQ-8)。使用TAS-20筛选匹配的健康对照。临床和人口统计学变量在情胸腺和非情胸腺之间进行了比较。回归模型用于找到述情障碍的决定因素。用线性回归模型估计述情障碍对QoL的影响。
结果：98例患者被纳入。56.1％的PwP和28.8％的对照组为情胸腺（p<0.001）。教育水平（OR0.86）和NMSS尿评分（OR1.09）决定了述情障碍和TAS-20评分。述情障碍是QoL的独立决定因素。
结论：述情障碍是PwP中普遍存在的独立非运动症状，对QoL有影响。低教育水平和泌尿症状是述情障碍的重要决定因素。
方法：招募帕金森病患者。应用了以下工具：运动障碍协会统一帕金森病评定量表（MDS-UPDRS），非运动症状量表（NMSS），蒙特利尔认知评估（MoCA）多伦多述情障碍量表(TAS-20)和帕金森病问卷(PDQ-8)。使用TAS-20筛选匹配的健康对照。临床和人口统计学变量在情胸腺和非情胸腺之间进行了比较。回归模型用于找到述情障碍的决定因素。用线性回归模型估计述情障碍对QoL的影响。
结果：98例患者被纳入。56.1％的PwP和28.8％的对照组为情胸腺（p<0.001）。教育水平（OR0.86）和NMSS尿评分（OR1.09）决定了述情障碍和TAS-20评分。述情障碍是QoL的独立决定因素。
结论：述情障碍是PwP中普遍存在的独立非运动症状，对QoL有影响。低教育水平和泌尿症状是述情障碍的重要决定因素。
