Abstract：
Cardiovascular diseases (CVD) are one of the most important causes of death worldwide. Dyslipidemia is one of the main causal risk factors for CVD that can be controlled by modifying lifestyle, which entails the use of healthy diets containing functional foods. The present study was conducted to summarize the effects of Spirulina on the lipid profile in previous randomized controlled trials.
MEDLINE, Scopus, Clarivate Analytics Web of Science, and the Cochrane Library databases were searched systematically until January 2023, for clinical interventions that investigated the effect of Spirulina supplementation on plasma lipid profile concentrations.
ooled results of 20 studies (with 23 arms and 1076 participants) indicated that Spirulina intervention significantly reduced LDL-C (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05), TC (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) and TG (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) levels while HDL-C levels were significantly increased (SMD: 0.3, 95% CI: 0.0, 0.6, P<0.05).
The findings of the present meta-analysis and review show the usefulness of supplementing with Spirulina in improving serum levels of TC, TG, LDL-C, and HDL-C.
MEDLINE, Scopus, Clarivate Analytics Web of Science, and the Cochrane Library databases were searched systematically until January 2023, for clinical interventions that investigated the effect of Spirulina supplementation on plasma lipid profile concentrations.
ooled results of 20 studies (with 23 arms and 1076 participants) indicated that Spirulina intervention significantly reduced LDL-C (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05), TC (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) and TG (SMD: -0.6, 95% CI: -0.9, -0.2, P<0.05) levels while HDL-C levels were significantly increased (SMD: 0.3, 95% CI: 0.0, 0.6, P<0.05).
The findings of the present meta-analysis and review show the usefulness of supplementing with Spirulina in improving serum levels of TC, TG, LDL-C, and HDL-C.
摘要：
背景：心血管疾病（CVD）是世界范围内最重要的死亡原因之一。血脂异常是心血管疾病的主要危险因素之一，可以通过改变生活方式来控制。这需要使用含有功能性食品的健康饮食。本研究旨在总结螺旋藻对先前随机对照试验中的脂质分布的影响。
方法：MEDLINE，Scopus,ClarivateAnalyticsWebofScience,系统检索CochraneLibrary数据库,直至2023年1月,研究补充螺旋藻对血脂谱浓度影响的临床干预措施.
结果：20项研究（23组和1076名参与者）的总体结果表明，螺旋藻干预显着降低了LDL-C（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05），TC（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05）和TG（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05）水平，而HDL-C水平显着升高（SMD：0.3，95％CI：0.0，0.6，P<0.05）。
结论：本荟萃分析和综述的结果表明，补充螺旋藻可改善血清TC水平，TG,LDL-C,和HDL-C
方法：MEDLINE，Scopus,ClarivateAnalyticsWebofScience,系统检索CochraneLibrary数据库,直至2023年1月,研究补充螺旋藻对血脂谱浓度影响的临床干预措施.
结果：20项研究（23组和1076名参与者）的总体结果表明，螺旋藻干预显着降低了LDL-C（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05），TC（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05）和TG（SMD：-0.6，95％CI：-0.9，-0.2，P<0.05）水平，而HDL-C水平显着升高（SMD：0.3，95％CI：0.0，0.6，P<0.05）。
结论：本荟萃分析和综述的结果表明，补充螺旋藻可改善血清TC水平，TG,LDL-C,和HDL-C
