Abstract：
UNASSIGNED: The purpose of this study was to investigate resting-state interhemispheric functional connectivity in patients with schizophrenia and refractory auditory verbal hallucinations (RAVHs) by using voxel-mirrored homotopic connectivity (VMHC).
UNASSIGNED: Thirty-four patients with schizophrenia and RAVHs (RAVH group), 23 patients with schizophrenia but no auditory verbal hallucinations (non-AVH group), and 28 matched healthy volunteers (healthy control group) were recruited in China. VMHC analyses were used to identify brain areas with significant differences in functional connectivity among the three groups, and correlations between symptom scores and neurological measures were examined.
UNASSIGNED: VMHC analyses showed aberrant bilateral connectivity between several homotopic brain regions: the RAVH and non-AVH groups showed differences in bilateral connectivity of the superior and middle temporal gyri, and the RAVH and healthy control groups showed differences in bilateral connectivity of the gyrus rectus, inferior frontal gyrus, and putamen. In addition, interhemispheric connectivity of the superior and middle temporal gyri correlated with patients\' positive symptom scores.
UNASSIGNED: These findings may help to elucidate the pathophysiological mechanisms underlying auditory verbal hallucinations. The results revealed interhemispheric functional dysconnectivity among patients with schizophrenia and suggest that the dysconnectivity of homotopic brain regions may play an important role in the development of auditory verbal hallucinations.
UNASSIGNED: Thirty-four patients with schizophrenia and RAVHs (RAVH group), 23 patients with schizophrenia but no auditory verbal hallucinations (non-AVH group), and 28 matched healthy volunteers (healthy control group) were recruited in China. VMHC analyses were used to identify brain areas with significant differences in functional connectivity among the three groups, and correlations between symptom scores and neurological measures were examined.
UNASSIGNED: VMHC analyses showed aberrant bilateral connectivity between several homotopic brain regions: the RAVH and non-AVH groups showed differences in bilateral connectivity of the superior and middle temporal gyri, and the RAVH and healthy control groups showed differences in bilateral connectivity of the gyrus rectus, inferior frontal gyrus, and putamen. In addition, interhemispheric connectivity of the superior and middle temporal gyri correlated with patients\' positive symptom scores.
UNASSIGNED: These findings may help to elucidate the pathophysiological mechanisms underlying auditory verbal hallucinations. The results revealed interhemispheric functional dysconnectivity among patients with schizophrenia and suggest that the dysconnectivity of homotopic brain regions may play an important role in the development of auditory verbal hallucinations.
摘要：
■这项研究的目的是通过使用体素镜像同位连接（VMHC）研究精神分裂症和难治性听觉言语幻觉（RAVH）患者的静息状态半球间功能连接。
■34例精神分裂症和RAVH患者（RAVH组），23例精神分裂症但无听觉言语幻觉的患者（非AVH组），并在中国招募28名匹配的健康志愿者（健康对照组）。VMHC分析用于确定三组之间功能连接存在显着差异的大脑区域，并检查了症状评分和神经系统指标之间的相关性。
■VMHC分析显示几个同位脑区域之间的异常双侧连通性：RAVH和非AVH组显示上颞中回的双侧连通性存在差异，RAVH组和健康对照组的双侧直肌连接存在差异，额下回,还有壳核.此外,上和中颞回的半球间连通性与患者的阳性症状评分相关。
■这些发现可能有助于阐明听觉言语幻觉的病理生理机制。结果揭示了精神分裂症患者的半球间功能连接障碍，并表明同位脑区的连接障碍可能在听觉言语幻觉的发展中起重要作用。
■34例精神分裂症和RAVH患者（RAVH组），23例精神分裂症但无听觉言语幻觉的患者（非AVH组），并在中国招募28名匹配的健康志愿者（健康对照组）。VMHC分析用于确定三组之间功能连接存在显着差异的大脑区域，并检查了症状评分和神经系统指标之间的相关性。
■VMHC分析显示几个同位脑区域之间的异常双侧连通性：RAVH和非AVH组显示上颞中回的双侧连通性存在差异，RAVH组和健康对照组的双侧直肌连接存在差异，额下回,还有壳核.此外,上和中颞回的半球间连通性与患者的阳性症状评分相关。
■这些发现可能有助于阐明听觉言语幻觉的病理生理机制。结果揭示了精神分裂症患者的半球间功能连接障碍，并表明同位脑区的连接障碍可能在听觉言语幻觉的发展中起重要作用。
