Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.

通过 WAVE 调节复合物介导的肌动蛋白重组来协调突触功能。

• 影响指数: 12.153
• 发表时间: 2023 06 1
• 来源期刊: Exp Mol Med
• DOI: 10.1038/s12276-023-01004-1
• PMID: 37258575
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Han KA,Ko J

Mesh: Actins / metabolism; Wiskott-Aldrich Syndrome Protein Family / metabolism; Carrier Proteins; Neurons / metabolism

Abstract

The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

摘要

WAVE监管综合体(WRC)，由五个组件组成-Cyfip1/Sra1，WAVE/Scar，阿比,Nap1/Nckap1和Brk1/HSPC300-对于真核细胞中正确的肌动蛋白细胞骨架动力学和重塑至关重要，可能通过将各种图案化信号与Arp2/3介导的肌动蛋白成核相匹配。最近的研究越来越多的证据揭示了WRC在神经元中的不同功能，证明了其在指示分子复合物组装以形成各种跨突触信号的关键作用。在这次审查中,我们讨论了最近关于WRC在调节突触特性中的生理作用的令人兴奋的发现，并强调了WRC功能障碍在各种脑疾病中的参与。