Abstract：
Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium-activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.
摘要：
钾(K+)通道建立并维持大多数活细胞的静息潜能。它们的活性主要受膜电压或跨细胞膜的K+梯度调节。然而,许多细胞也表达小电导钙激活钾（SK）通道，它们具有独特的能力来翻译细胞内第二信使水平的变化，Ca2+对膜K+电导的变化，因此,静息膜电位。本文回顾了该结构，存在,分布，和SK通道的功能，他们的药理调制，以及它们在健康和疾病中的作用，强调伤害性和疼痛。
