PDF(Pubmed)
Abstract：
UNASSIGNED: Psychogenic non-epileptic seizure (PNES) is the most common non-epileptic disorder in patients referring to epilepsy centers. Contrary to common beliefs about the disease\'s harmlessness, the death rate of PNES patients is similar to drug-resistant epilepsy. Meanwhile, the molecular pathomechanism of PNES is unknown with very limited related research. Thus, the aim of this in silico study was to find different proteins and hormones associated with PNES via a systems biology approach.
UNASSIGNED: Different bioinformatics databases and literature review were used to find proteins associated with PNES. The protein-hormone interaction network of PNES was constructed to discover its most influential compartments. The pathways associated with PNES pathomechanism were found by enrichment analysis of the identified proteins. Besides, the relationship between PNES-related molecules and psychiatric diseases was discovered, and the brain regions that could express altered levels of blood proteins were discovered.
UNASSIGNED: Eight genes and three hormones were found associated with PNES through the review process. Proopiomelanocortin (POMC), neuropeptide Y (NPY), cortisol, norepinephrine, and brain-derived neurotrophic factor (BDNF) were identified to have a high impact on the disease pathogenesis network. Moreover, activation of Janus kinase-signaling transducer and activator of transcription (JAK-STAT) and JAK, as well as signaling of growth hormone receptor, phosphatidylinositol 3-kinase /protein kinase B (PI3K/AKT), and neurotrophin were found associated with PNES molecular mechanism. Several psychiatric diseases such as depression, schizophrenia, and alcohol-related disorders were shown to be associated with PNES predominantly through signaling molecules.
UNASSIGNED: This study was the first to gather the biochemicals associated with PNES. Multiple components and pathways and several psychiatric diseases associated with PNES, and some brain regions that could be altered during PNES were suggested, which should be confirmed in further studies. Altogether, these findings could be used in future molecular research on PNES patients.
UNASSIGNED: Different bioinformatics databases and literature review were used to find proteins associated with PNES. The protein-hormone interaction network of PNES was constructed to discover its most influential compartments. The pathways associated with PNES pathomechanism were found by enrichment analysis of the identified proteins. Besides, the relationship between PNES-related molecules and psychiatric diseases was discovered, and the brain regions that could express altered levels of blood proteins were discovered.
UNASSIGNED: Eight genes and three hormones were found associated with PNES through the review process. Proopiomelanocortin (POMC), neuropeptide Y (NPY), cortisol, norepinephrine, and brain-derived neurotrophic factor (BDNF) were identified to have a high impact on the disease pathogenesis network. Moreover, activation of Janus kinase-signaling transducer and activator of transcription (JAK-STAT) and JAK, as well as signaling of growth hormone receptor, phosphatidylinositol 3-kinase /protein kinase B (PI3K/AKT), and neurotrophin were found associated with PNES molecular mechanism. Several psychiatric diseases such as depression, schizophrenia, and alcohol-related disorders were shown to be associated with PNES predominantly through signaling molecules.
UNASSIGNED: This study was the first to gather the biochemicals associated with PNES. Multiple components and pathways and several psychiatric diseases associated with PNES, and some brain regions that could be altered during PNES were suggested, which should be confirmed in further studies. Altogether, these findings could be used in future molecular research on PNES patients.
摘要：
■精神性非癫痫发作（PNES）是指癫痫中心患者中最常见的非癫痫性疾病。与人们对这种疾病无害的普遍看法相反，PNES患者的死亡率与耐药癫痫相似。同时,PNES的分子病理机制尚不清楚，相关研究非常有限。因此，这项计算机模拟研究的目的是通过系统生物学方法发现与PNES相关的不同蛋白质和激素.
■使用不同的生物信息学数据库和文献综述来寻找与PNES相关的蛋白质。构建了PNES的蛋白质-激素相互作用网络，以发现其最有影响力的隔室。通过对鉴定的蛋白质的富集分析发现了与PNES病理机制相关的途径。此外,发现了PNES相关分子与精神疾病之间的关系，并发现了能够表达改变水平的血液蛋白的大脑区域。
■通过回顾过程发现了与PNES相关的八个基因和三个激素。Proopiomelanocortin（POMC），神经肽Y（NPY），皮质醇,去甲肾上腺素,和脑源性神经营养因子（BDNF）被认为对疾病的发病机制网络有很高的影响。此外，Janus激酶信号转导子和转录激活子（JAK-STAT）和JAK的激活，以及生长激素受体的信号，磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT),发现神经营养因子与PNES分子机制有关。一些精神疾病，如抑郁症，精神分裂症,和酒精相关疾病被证明主要通过信号分子与PNES相关.
■这项研究是第一个收集与PNES相关的生化物质的研究。与PNES相关的多种成分和途径以及几种精神疾病，并提出了一些在PNES期间可能会改变的大脑区域，这应该在进一步的研究中得到证实。总之,这些发现可用于未来对PNES患者的分子研究.
■使用不同的生物信息学数据库和文献综述来寻找与PNES相关的蛋白质。构建了PNES的蛋白质-激素相互作用网络，以发现其最有影响力的隔室。通过对鉴定的蛋白质的富集分析发现了与PNES病理机制相关的途径。此外,发现了PNES相关分子与精神疾病之间的关系，并发现了能够表达改变水平的血液蛋白的大脑区域。
■通过回顾过程发现了与PNES相关的八个基因和三个激素。Proopiomelanocortin（POMC），神经肽Y（NPY），皮质醇,去甲肾上腺素,和脑源性神经营养因子（BDNF）被认为对疾病的发病机制网络有很高的影响。此外，Janus激酶信号转导子和转录激活子（JAK-STAT）和JAK的激活，以及生长激素受体的信号，磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT),发现神经营养因子与PNES分子机制有关。一些精神疾病，如抑郁症，精神分裂症,和酒精相关疾病被证明主要通过信号分子与PNES相关.
■这项研究是第一个收集与PNES相关的生化物质的研究。与PNES相关的多种成分和途径以及几种精神疾病，并提出了一些在PNES期间可能会改变的大脑区域，这应该在进一步的研究中得到证实。总之,这些发现可用于未来对PNES患者的分子研究.
