PDF(Pubmed)
Abstract：
Objective: Computed tomography (CT) images of the temporal bone of large vestibular aqueduct syndrome (LVAS) patients were used to establish 3D numerical models based on the structure of the inner ear, which are, in turn, used to construct inner ear fluid-solid coupling models. The physiological features and pathophysiology of LVAS were analyzed from a biomechanical perspective using finite element analysis. Methods: CT images of the temporal bone were collected from five children attending the Second Hospital of Dalian Medical University in 2022. The CT images were used to build 3D models of the inner ear containing the vestibular aqueduct (VA) by Mimics and Geomagic software, and round window membrane models and fluid-solid coupling models were built by ANSYS software to perform fluid-solid coupling analysis. Results: By applying different pressure loads, the deformation of the round window membranes occurred, and their trend was basically the same as that of the load. The deformation and stress of the round window membranes increased with the increase in load. Under the same load, the deformation and stress of the round window membranes increased with the expansion of the midpoint width of the VA. Conclusion: CT images of the temporal bone used clinically could establish a complete 3D numerical model of the inner ear containing VA. Fluctuations in cerebrospinal fluid pressure could affect inner ear pressure, and VA had a limiting effect on the pressure from cerebrospinal fluid. The larger the VA, the smaller the limiting effect on the pressure.
摘要：
目的:利用大前庭水管综合征(LVAS)患者颞骨的计算机断层扫描(CT)图像,根据内耳结构建立三维数值模型,它们是，反过来,用于构建内耳流固耦合模型。采用有限元分析方法从生物力学角度分析了LVAS的生理特点和病理生理学。方法:收集2022年在大连医科大学附属第二医院就诊的5例儿童颞骨CT图像。通过Mimics和Geomagic软件，将CT图像用于构建包含前庭水管（VA）的内耳的3D模型。利用ANSYS软件建立圆窗膜模型和流固耦合模型进行流固耦合分析。结果：通过施加不同的压力载荷，圆窗膜发生了变形，它们的趋势与负载的趋势基本相同。圆窗膜的变形和应力随载荷的增加而增加。在相同的负载下，圆窗膜的变形和应力随着VA中点宽度的扩大而增加。结论:临床应用颞骨CT图像可建立完整的内耳含VA的三维数值模型。脑脊液压力的波动会影响内耳压力，VA对脑脊液压力有限制作用。VA越大，对压力的限制作用越小。
