PDF(Pubmed)
Abstract：
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people\'s life expectancy and patients\' quality of life. Oxidative stress (OS) aggravates the development of diseases in glycolipid metabolism. Radical oxygen species (ROS) is a key factor in the signal transduction of OS, which can regulate cell apoptosis and contribute to inflammation. Currently, chemotherapies are the main method to treat disorders of glycolipid metabolism, but this can lead to drug resistance and damage to normal organs. Botanical drugs are an important source of new drugs. They are widely found in nature with availability, high practicality, and low cost. There is increasing evidence that herbal medicine has definite therapeutic effects on glycolipid metabolic diseases. Objective: This study aims to provide a valuable method for the treatment of glycolipid metabolic diseases with botanical drugs from the perspective of ROS regulation by botanical drugs and to further promote the development of effective drugs for the clinical treatment of glycolipid metabolic diseases. Methods: Using herb*, plant medicine, Chinese herbal medicine, phytochemicals, natural medicine, phytomedicine, plant extract, botanical drug, ROS, oxygen free radicals, oxygen radical, oxidizing agent, glucose and lipid metabolism, saccharometabolism, glycometabolism, lipid metabolism, blood glucose, lipoprotein, triglyceride, fatty liver, atherosclerosis, obesity, diabetes, dysglycemia, NAFLD, and DM as keywords or subject terms, relevant literature was retrieved from Web of Science and PubMed databases from 2013 to 2022 and was summarized. Results: Botanical drugs can regulate ROS by regulating mitochondrial function, endoplasmic reticulum, phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT), erythroid 2-related factor 2 (Nrf-2), nuclear factor κB (NF-κB), and other signaling pathways to improve OS and treat glucolipid metabolic diseases. Conclusion: The regulation of ROS by botanical drugs is multi-mechanism and multifaceted. Both cell studies and animal experiments have demonstrated the effectiveness of botanical drugs in the treatment of glycolipid metabolic diseases by regulating ROS. However, studies on safety need to be further improved, and more studies are needed to support the clinical application of botanical drugs.
摘要：
背景:糖脂代谢性疾病在全球范围内的发病率极高,这极大地阻碍了人们的预期寿命和患者的生活质量。氧化应激（OS）加重糖脂代谢疾病的发展。自由基氧(ROS)是OS信号转导的关键因素,可以调节细胞凋亡并促进炎症反应。目前,化疗是治疗糖脂代谢紊乱的主要方法,但这会导致耐药性和对正常器官的损害。植物药是新药的重要来源。它们广泛存在于自然界中，具有可用性，实用性高,和低成本。越来越多的证据表明，草药对糖脂代谢疾病具有明确的治疗作用。目的:本研究旨在从植物性药物对ROS的调控角度,为植物性药物治疗糖脂代谢病提供一种有价值的方法,进一步促进临床治疗糖脂代谢病的有效药物的开发。方法：使用草药*，植物药,中草药,植物化学物质,天然药物,植物医学,植物提取物,植物药,ROS,氧自由基,氧自由基,氧化剂，葡萄糖和脂质代谢，糖代谢，糖代谢，脂质代谢，血糖，脂蛋白，甘油三酯，脂肪肝,动脉粥样硬化,肥胖，糖尿病,血糖异常，NAFLD,和DM作为关键字或主题词，从2013年至2022年的WebofScience和PubMed数据库检索了相关文献并进行了总结.结果:植物性药物可通过调节线粒体功能调节ROS,内质网，磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT),红系2相关因子2(Nrf-2)，核因子κB(NF-κB),等信号通路改善OS和治疗糖脂代谢疾病。结论:植物性药物对ROS的调控机制是多方面的。细胞研究和动物实验都证明了植物性药物通过调节ROS治疗糖脂代谢疾病的有效性。然而,关于安全的研究需要进一步改进，需要更多的研究来支持植物药的临床应用。
