PDF(Pubmed)
Abstract：
UNASSIGNED: We performed a systematic review and meta-analysis of the association between retinal imaging parameters and Alzheimer\'s disease (AD).
UNASSIGNED: PubMed, EMBASE, and Scopus were systematically searched for prospective and observational studies. Included studies had AD case definition based on brain amyloid beta (Aβ) status. Study quality assessment was performed. Random-effects meta-analyses of standardized mean difference, correlation, and diagnostic accuracy were conducted.
UNASSIGNED: Thirty-eight studies were included. There was weak evidence of peripapillary retinal nerve fiber layer thinning on optical coherence tomography (OCT) (p = 0.14, 11 studies, n = 828), increased foveal avascular zone area on OCT-angiography (p = 0.18, four studies, n = 207), and reduced arteriole and venule vessel fractal dimension on fundus photography (p < 0.001 and p = 0.08, respectively, three studies, n = 297) among AD cases.
UNASSIGNED: Retinal imaging parameters appear to be associated with AD. Small study sizes and heterogeneity in imaging methods and reporting make it difficult to determine utility of these changes as AD biomarkers.
UNASSIGNED: We performed a systematic review on retinal imaging and Alzheimer\'s disease (AD).We only included studies in which cases were based on brain amyloid beta status.Several retinal biomarkers were associated with AD but clinical utility is uncertain.Studies should focus on biomarker-defined AD and use standardized imaging methods.
UNASSIGNED: PubMed, EMBASE, and Scopus were systematically searched for prospective and observational studies. Included studies had AD case definition based on brain amyloid beta (Aβ) status. Study quality assessment was performed. Random-effects meta-analyses of standardized mean difference, correlation, and diagnostic accuracy were conducted.
UNASSIGNED: Thirty-eight studies were included. There was weak evidence of peripapillary retinal nerve fiber layer thinning on optical coherence tomography (OCT) (p = 0.14, 11 studies, n = 828), increased foveal avascular zone area on OCT-angiography (p = 0.18, four studies, n = 207), and reduced arteriole and venule vessel fractal dimension on fundus photography (p < 0.001 and p = 0.08, respectively, three studies, n = 297) among AD cases.
UNASSIGNED: Retinal imaging parameters appear to be associated with AD. Small study sizes and heterogeneity in imaging methods and reporting make it difficult to determine utility of these changes as AD biomarkers.
UNASSIGNED: We performed a systematic review on retinal imaging and Alzheimer\'s disease (AD).We only included studies in which cases were based on brain amyloid beta status.Several retinal biomarkers were associated with AD but clinical utility is uncertain.Studies should focus on biomarker-defined AD and use standardized imaging methods.
摘要：
■我们对视网膜成像参数与阿尔茨海默病（AD）之间的关联进行了系统评价和荟萃分析。
■PubMed,EMBASE,和Scopus被系统地搜索前瞻性和观察性研究。纳入的研究具有基于脑淀粉样β(Aβ)状态的AD病例定义。进行研究质量评估。标准化均值差异的随机效应荟萃分析，相关性，并进行了诊断准确性。
■纳入了38项研究。在光学相干断层扫描（OCT）上，乳头状周围视网膜神经纤维层变薄的证据薄弱（p=0.14，11项研究，n=828)，OCT血管造影术上中央凹无血管区面积增加(p=0.18，四项研究，n=207)，眼底照相时小动脉和小静脉血管分形维数降低(分别为p<0.001和p=0.08，三项研究,AD病例中n=297）。
■视网膜成像参数似乎与AD相关。成像方法和报告中的小研究规模和异质性使得难以确定这些变化作为AD生物标志物的效用。
■我们对视网膜成像和阿尔茨海默病（AD）进行了系统评价。我们仅纳入了基于脑淀粉样蛋白β状态的病例研究。几种视网膜生物标志物与AD相关，但临床应用尚不确定。研究应集中于生物标志物定义的AD，并使用标准化的成像方法。
■PubMed,EMBASE,和Scopus被系统地搜索前瞻性和观察性研究。纳入的研究具有基于脑淀粉样β(Aβ)状态的AD病例定义。进行研究质量评估。标准化均值差异的随机效应荟萃分析，相关性，并进行了诊断准确性。
■纳入了38项研究。在光学相干断层扫描（OCT）上，乳头状周围视网膜神经纤维层变薄的证据薄弱（p=0.14，11项研究，n=828)，OCT血管造影术上中央凹无血管区面积增加(p=0.18，四项研究，n=207)，眼底照相时小动脉和小静脉血管分形维数降低(分别为p<0.001和p=0.08，三项研究,AD病例中n=297）。
■视网膜成像参数似乎与AD相关。成像方法和报告中的小研究规模和异质性使得难以确定这些变化作为AD生物标志物的效用。
■我们对视网膜成像和阿尔茨海默病（AD）进行了系统评价。我们仅纳入了基于脑淀粉样蛋白β状态的病例研究。几种视网膜生物标志物与AD相关，但临床应用尚不确定。研究应集中于生物标志物定义的AD，并使用标准化的成像方法。
