Abstract：
BACKGROUND: Cutaneous B-cell lymphoma (CBCL) is part of dermatopathological routine diagnostics. However, in contrast to cutaneous T-cell lymphomas, there are only a few studies on the prevalence and possible clinical impact of lymphatic vessel involvement. Therefore, this pilot study aimed to quantify the prevalence of lymphovascular involvement in CBCL and to assess the association between lymphovascular involvement and recurrence.
METHODS: Thirty-nine patients from two tertiary care hospitals diagnosed with CBCL were retrospectively identified and their biopsies were histopathologically examined for the presence of lymphatic vessel involvement using H&E stain, and CD20 and D2-40 immunohistochemistry. Clinical data were retrieved from our digital documentation files.
RESULTS: Thirty patients were included in the evaluation (nPCFCL = 15, nPCMZL = 10, and nPCLBCL = 5). Lymphovascular involvement occurred in all three types of lymphoma and was present in 14/30 specimens. The presence of lymphatic involvement did not show a significant impact on recurrence rate (p = 0.150).
CONCLUSIONS: This immunohistochemical pilot study shows that lymphovascular involvement is a relatively frequent finding in primary CBCL. Although no definitive conclusion can be drawn from our findings because of the small sample size, there were no strong signs of tendencies for recurrence in either group. Future studies with larger sample size are warranted to assess the possible clinical implications.
METHODS: Thirty-nine patients from two tertiary care hospitals diagnosed with CBCL were retrospectively identified and their biopsies were histopathologically examined for the presence of lymphatic vessel involvement using H&E stain, and CD20 and D2-40 immunohistochemistry. Clinical data were retrieved from our digital documentation files.
RESULTS: Thirty patients were included in the evaluation (nPCFCL = 15, nPCMZL = 10, and nPCLBCL = 5). Lymphovascular involvement occurred in all three types of lymphoma and was present in 14/30 specimens. The presence of lymphatic involvement did not show a significant impact on recurrence rate (p = 0.150).
CONCLUSIONS: This immunohistochemical pilot study shows that lymphovascular involvement is a relatively frequent finding in primary CBCL. Although no definitive conclusion can be drawn from our findings because of the small sample size, there were no strong signs of tendencies for recurrence in either group. Future studies with larger sample size are warranted to assess the possible clinical implications.
摘要：
背景：皮肤B细胞淋巴瘤（CBCL）是皮肤病理学常规诊断的一部分。然而,与皮肤T细胞淋巴瘤相反，关于淋巴管受累的患病率和可能的临床影响的研究很少。因此,这项初步研究旨在量化CBCL中淋巴血管受累的患病率,并评估淋巴血管受累与复发之间的关联.
方法：回顾性鉴定了来自两家三级医院的39例被诊断为CBCL的患者，并使用H＆E染色对其活检进行了组织病理学检查，以确定是否存在淋巴管受累。和CD20和D2-40免疫组织化学。从我们的数字文档文件中检索临床数据。
结果：30例患者纳入评估（nPCFCL=15，nPCMZL=10，nPCLBCL=5）。淋巴管受累发生在所有三种类型的淋巴瘤中，并且存在于14/30个标本中。淋巴受累的存在对复发率没有显着影响（p=0.150）。
结论：这项免疫组织化学初步研究表明，在原发性CBCL中，淋巴管受累是一个相对常见的发现。尽管由于样本量小，我们的发现无法得出明确的结论，两组均无明显的复发倾向.未来有必要进行更大样本量的研究，以评估可能的临床意义。
方法：回顾性鉴定了来自两家三级医院的39例被诊断为CBCL的患者，并使用H＆E染色对其活检进行了组织病理学检查，以确定是否存在淋巴管受累。和CD20和D2-40免疫组织化学。从我们的数字文档文件中检索临床数据。
结果：30例患者纳入评估（nPCFCL=15，nPCMZL=10，nPCLBCL=5）。淋巴管受累发生在所有三种类型的淋巴瘤中，并且存在于14/30个标本中。淋巴受累的存在对复发率没有显着影响（p=0.150）。
结论：这项免疫组织化学初步研究表明，在原发性CBCL中，淋巴管受累是一个相对常见的发现。尽管由于样本量小，我们的发现无法得出明确的结论，两组均无明显的复发倾向.未来有必要进行更大样本量的研究，以评估可能的临床意义。
