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Abstract：
UNASSIGNED: To analyze the detection rate, in vitro susceptibility to antibiotics, and carbapenemase types of carbapenem-resistant Enterobacteriaceae (CRE) strains in the clinical samples of a hospital and to provide support for the prevention, control and treatment of CRE-related infections.
UNASSIGNED: Clinical specimens were examined according to the operating procedures of bacteriological tests. Species identification and in vitro drug susceptibility testing were performed on the isolated strains. Carbapenemase inhibitor enhancement testing, which combined the use of 3-aminobenzeneboronic acid and ethylenediaminetetraacetic acid, was conducted to identify the types of carbapenemase in the CRE strains.
UNASSIGNED: In 2021, 2215 CRE strains were isolated from 157196 clinical samples collected in this hospital, presenting a detection rate of 1.4% (2215/157196). A total of 1134 non-repetitive strains of CRE were isolated from 903 patients. The main sources of samples were respiratory tract (494/1134, 43.6%), secretion (191/1134, 16.8%) and blood (173/1134, 15.3%) samples. The cases with the same CRE strain isolated from the samples of two, three and four sites accounted for 12.5%, 4.9%, and 1.1%, respectively. The most common species was Klebsiella pneumoniae (883/1134, 77.9%), followed by Enterobacter cloacae complex (107/1134, 9.4%) and Escherichia coli (96/1134, 8.5%). The rates of resistance to polymyxin B and tigecycline of different species of CRE strains were not significantly different ( P<0.05). Serine carbapenemase-producing strains, metallo-β-lactamase-producing strains, and those producing both enzymes accounted for 82.6% (809/979), 17.2% (168/979), and 0.2% (2/979), respectively.
UNASSIGNED: CRE strains are frequently isolated from samples collected from the respiratory tract, secretion, and blood. The most common strain is serine carbapenemase-producing K. pneumoniae, which has a high resistance rate to various antimicrobial drugs, and risk factors of its associated infections deserve more attention.
UNASSIGNED: Clinical specimens were examined according to the operating procedures of bacteriological tests. Species identification and in vitro drug susceptibility testing were performed on the isolated strains. Carbapenemase inhibitor enhancement testing, which combined the use of 3-aminobenzeneboronic acid and ethylenediaminetetraacetic acid, was conducted to identify the types of carbapenemase in the CRE strains.
UNASSIGNED: In 2021, 2215 CRE strains were isolated from 157196 clinical samples collected in this hospital, presenting a detection rate of 1.4% (2215/157196). A total of 1134 non-repetitive strains of CRE were isolated from 903 patients. The main sources of samples were respiratory tract (494/1134, 43.6%), secretion (191/1134, 16.8%) and blood (173/1134, 15.3%) samples. The cases with the same CRE strain isolated from the samples of two, three and four sites accounted for 12.5%, 4.9%, and 1.1%, respectively. The most common species was Klebsiella pneumoniae (883/1134, 77.9%), followed by Enterobacter cloacae complex (107/1134, 9.4%) and Escherichia coli (96/1134, 8.5%). The rates of resistance to polymyxin B and tigecycline of different species of CRE strains were not significantly different ( P<0.05). Serine carbapenemase-producing strains, metallo-β-lactamase-producing strains, and those producing both enzymes accounted for 82.6% (809/979), 17.2% (168/979), and 0.2% (2/979), respectively.
UNASSIGNED: CRE strains are frequently isolated from samples collected from the respiratory tract, secretion, and blood. The most common strain is serine carbapenemase-producing K. pneumoniae, which has a high resistance rate to various antimicrobial drugs, and risk factors of its associated infections deserve more attention.
摘要：
■要分析检测率，对抗生素的体外敏感性，和碳青霉烯酶类型的耐碳青霉烯类肠杆菌(CRE)菌株在医院临床样本中的应用,CRE相关感染的控制和治疗。
■根据细菌学测试的操作程序检查临床标本。对分离的菌株进行物种鉴定和体外药敏试验。碳青霉烯酶抑制剂增强试验，结合使用3-氨基苯硼酸和乙二胺四乙酸，进行鉴定CRE菌株中碳青霉烯酶的类型。
■2021年，从该医院收集的157196个临床样本中分离出2215个CRE菌株，检出率为1.4%(2215/157196)。从903名患者中分离出1134种非重复CRE菌株。主要样本来源为呼吸道(494/1134,43.6%),分泌物(191/1134，16.8%)和血液(173/1134，15.3%)样本。从两个样品中分离出具有相同CRE菌株的情况，三个和四个网站占12.5%，4.9%,1.1%，分别。最常见的是肺炎克雷伯菌（883/1134，77.9％），其次是阴沟肠杆菌（107/1134，9.4％）和大肠杆菌（96/1134，8.5％）。不同品种CRE菌株对多粘菌素B和替加环素的耐药率差异无统计学意义(P>0.05)。丝氨酸碳青霉烯酶产生菌株，产生金属β-内酰胺酶的菌株，两种酶的产量占82.6%(809/979)，17.2%（168/979），和0.2%(2/979)，分别。
■CRE菌株通常从呼吸道收集的样品中分离出来，分泌，还有血.最常见的菌株是产生丝氨酸碳青霉烯酶的肺炎克雷伯菌，对各种抗菌药物有很高的耐药率，及其相关感染的危险因素值得更多关注。
■根据细菌学测试的操作程序检查临床标本。对分离的菌株进行物种鉴定和体外药敏试验。碳青霉烯酶抑制剂增强试验，结合使用3-氨基苯硼酸和乙二胺四乙酸，进行鉴定CRE菌株中碳青霉烯酶的类型。
■2021年，从该医院收集的157196个临床样本中分离出2215个CRE菌株，检出率为1.4%(2215/157196)。从903名患者中分离出1134种非重复CRE菌株。主要样本来源为呼吸道(494/1134,43.6%),分泌物(191/1134，16.8%)和血液(173/1134，15.3%)样本。从两个样品中分离出具有相同CRE菌株的情况，三个和四个网站占12.5%，4.9%,1.1%，分别。最常见的是肺炎克雷伯菌（883/1134，77.9％），其次是阴沟肠杆菌（107/1134，9.4％）和大肠杆菌（96/1134，8.5％）。不同品种CRE菌株对多粘菌素B和替加环素的耐药率差异无统计学意义(P>0.05)。丝氨酸碳青霉烯酶产生菌株，产生金属β-内酰胺酶的菌株，两种酶的产量占82.6%(809/979)，17.2%（168/979），和0.2%(2/979)，分别。
■CRE菌株通常从呼吸道收集的样品中分离出来，分泌，还有血.最常见的菌株是产生丝氨酸碳青霉烯酶的肺炎克雷伯菌，对各种抗菌药物有很高的耐药率，及其相关感染的危险因素值得更多关注。
