PDF(Pubmed)
Abstract：
A thorough understanding of root and canal anatomy is crucial for successful root canal treatment outcomes. This systematic review aims to explore the published micro-CT studies investigated the anatomy of root and canal system in permanent mandibular first molars.
An electronic search was performed on Web of science, PubMed, and Scopus. Micro-CT journal studies investigated the root and canal anatomy of permanent double-rooted mandibular first molars were included. Data on study characteristics, objectives of interest, specifications of the studies, and micro-CT specifications were extracted. Risk of bias assessment (ROB) of the included studies was performed using Anatomical Quality Assessment (AQUA) tool. The extracted data were presented in tables and figures to present and synthesise the results. A meta-analysis was performed for the studies related to the prevalence of Vertucci\'s canal configurations, middle mesial canal (MMC) configurations, and Fan\'s isthmus types.
Amongst 1358 identified studies, thirty met the inclusion criteria. In terms of the objectives, the selected studies showed high anatomical variability in mandibular first molars. Twenty-two (73%), 25 (83%), and 12 (40%) of the studies reported the population/ethnicity, micro-CT specifications, and ethical approval, respectively. 28 (93%) studies did not disclose the method of sample size estimation. In only 6 (20%) of the studies, the authors had calibrated the assessment approaches. Mostly, a potential ROB was reported in domain 1 (objective(s) and subject characteristics) and domain 3 (methodology characterization). Whilst, low risk was reported in domains 2 (study design), 4 (descriptive anatomy), and 5 (reporting of results). The overall ROB was reported to be \'\'moderate\'\' in the vast majority of the studies (27/30). Meta-analysis results showed high levels of heterogeneity among the studies related to MMCs (I2 = 86%) and Fan\'s isthmus (I2 = 87%). As for the root canal configuration, pooled prevalence showed that Vertucci type IV and type I were the most prevalent in mesial and distal root canals, respectively.
Based on moderate risk of bias level of evidence, micro-CT studies have shown wide range of qualitative and quantitative data presentations of the roots and canals in mandibular first molars. Protocol and registration. The protocol of this systematic review was prospectively registered in the Open Science Framework database ( https://osf.io ) on 2022-06-20 with the registration number 10.17605/OSF.IO/EZP7K.
An electronic search was performed on Web of science, PubMed, and Scopus. Micro-CT journal studies investigated the root and canal anatomy of permanent double-rooted mandibular first molars were included. Data on study characteristics, objectives of interest, specifications of the studies, and micro-CT specifications were extracted. Risk of bias assessment (ROB) of the included studies was performed using Anatomical Quality Assessment (AQUA) tool. The extracted data were presented in tables and figures to present and synthesise the results. A meta-analysis was performed for the studies related to the prevalence of Vertucci\'s canal configurations, middle mesial canal (MMC) configurations, and Fan\'s isthmus types.
Amongst 1358 identified studies, thirty met the inclusion criteria. In terms of the objectives, the selected studies showed high anatomical variability in mandibular first molars. Twenty-two (73%), 25 (83%), and 12 (40%) of the studies reported the population/ethnicity, micro-CT specifications, and ethical approval, respectively. 28 (93%) studies did not disclose the method of sample size estimation. In only 6 (20%) of the studies, the authors had calibrated the assessment approaches. Mostly, a potential ROB was reported in domain 1 (objective(s) and subject characteristics) and domain 3 (methodology characterization). Whilst, low risk was reported in domains 2 (study design), 4 (descriptive anatomy), and 5 (reporting of results). The overall ROB was reported to be \'\'moderate\'\' in the vast majority of the studies (27/30). Meta-analysis results showed high levels of heterogeneity among the studies related to MMCs (I2 = 86%) and Fan\'s isthmus (I2 = 87%). As for the root canal configuration, pooled prevalence showed that Vertucci type IV and type I were the most prevalent in mesial and distal root canals, respectively.
Based on moderate risk of bias level of evidence, micro-CT studies have shown wide range of qualitative and quantitative data presentations of the roots and canals in mandibular first molars. Protocol and registration. The protocol of this systematic review was prospectively registered in the Open Science Framework database ( https://osf.io ) on 2022-06-20 with the registration number 10.17605/OSF.IO/EZP7K.
摘要：
背景：彻底了解根和管的解剖结构对于成功的根管治疗结果至关重要。本系统综述旨在探索已发表的显微CT研究，研究了下颌第一磨牙的根和管系统的解剖结构。
方法：在Webofscience上进行了电子搜索，PubMed,还有Scopus.Micro-CT期刊研究了永久性双根下颌第一磨牙的根和管解剖结构。有关研究特征的数据，感兴趣的目标，研究的规格，并提取了micro-CT规格。使用解剖学质量评估（AQUA）工具对纳入研究的偏倚风险进行评估（ROB）。所提取的数据呈现在表格和附图中以呈现和合成结果。对与Vertucci管构型患病率相关的研究进行了荟萃分析，中中管（MMC）构型，和风扇的地峡类型。
结果：在1358项确定的研究中，30符合纳入标准。在目标方面,选定的研究表明，下颌第一磨牙的解剖变异性很高。二十二（73%），25（83%），12项(40%)研究报告了人口/种族，Micro-CT规格,和道德认可，分别。28项(93%)研究没有披露样本量估计的方法。在只有6项（20%）的研究中，作者对评估方法进行了校准.大多数情况下,在结构域1(目标和受试者特征)和结构域3(方法学表征)中报道了潜在的ROB。同时,在领域2（研究设计）中报告了低风险，4（描述性解剖学），和5（结果报告）。在绝大多数研究中（27/30），总体ROB报告为“中等”。Meta分析结果显示,MMCs(I2=86%)和范峡部(I2=87%)的研究存在高度异质性。至于根管配置，合并患病率显示，VertucciIV型和I型在根管的内侧和远端最普遍，分别。
结论：基于证据的中度偏倚风险水平，Micro-CT研究显示了下颌第一磨牙根部和运河的定性和定量数据。协议和登记。这项系统评价的协议于2022-06-20年在开放科学框架数据库（https://osf.io）中进行了前瞻性注册，注册号为10.17605/OSF。IO/EZP7K。
方法：在Webofscience上进行了电子搜索，PubMed,还有Scopus.Micro-CT期刊研究了永久性双根下颌第一磨牙的根和管解剖结构。有关研究特征的数据，感兴趣的目标，研究的规格，并提取了micro-CT规格。使用解剖学质量评估（AQUA）工具对纳入研究的偏倚风险进行评估（ROB）。所提取的数据呈现在表格和附图中以呈现和合成结果。对与Vertucci管构型患病率相关的研究进行了荟萃分析，中中管（MMC）构型，和风扇的地峡类型。
结果：在1358项确定的研究中，30符合纳入标准。在目标方面,选定的研究表明，下颌第一磨牙的解剖变异性很高。二十二（73%），25（83%），12项(40%)研究报告了人口/种族，Micro-CT规格,和道德认可，分别。28项(93%)研究没有披露样本量估计的方法。在只有6项（20%）的研究中，作者对评估方法进行了校准.大多数情况下,在结构域1(目标和受试者特征)和结构域3(方法学表征)中报道了潜在的ROB。同时,在领域2（研究设计）中报告了低风险，4（描述性解剖学），和5（结果报告）。在绝大多数研究中（27/30），总体ROB报告为“中等”。Meta分析结果显示,MMCs(I2=86%)和范峡部(I2=87%)的研究存在高度异质性。至于根管配置，合并患病率显示，VertucciIV型和I型在根管的内侧和远端最普遍，分别。
结论：基于证据的中度偏倚风险水平，Micro-CT研究显示了下颌第一磨牙根部和运河的定性和定量数据。协议和登记。这项系统评价的协议于2022-06-20年在开放科学框架数据库（https://osf.io）中进行了前瞻性注册，注册号为10.17605/OSF。IO/EZP7K。
