Abstract：
Zosteriform cutaneous metastases from urothelial carcinoma are rare. Here, we report a 50-year-old male with urothelial carcinoma who presented with multiple tender, erythematous papulonodules in an L1-L3 distribution approximately 6 years after primary tumor diagnosis. He had no history of prior herpes zoster infection. Histopathology showed lobules and small nests of atypical epithelioid cells positive for GATA3, CK20, CK7, and p40 throughout the dermis and within lymphatic vessels highlighted by D2-40, consistent with cutaneous metastases from urothelial carcinoma. No perineural invasion or viral cytopathic change was present. The patient died approximately 8 months after diagnosis of cutaneous metastases. Since its first report in 1986, there have been only six cases of zosteriform cutaneous metastases from urothelial carcinoma. We review the prior literature including hypotheses of the pathogenesis of zosteriform cutaneous metastases, which remain incompletely understood.
摘要：
来自尿路上皮癌的带状疱疹样皮肤转移很少见。这里,我们报道了一名50岁的男性尿路上皮癌，他表现为多发触痛，原发性肿瘤诊断后约6年，L1-L3分布的红斑丘疹结节。既往无带状疱疹感染史。组织病理学显示，整个真皮和D2-40突出显示的淋巴管内GATA3，CK20，CK7和p40阳性的非典型上皮样细胞的小叶和小巢，与尿路上皮癌的皮肤转移一致。没有出现神经周侵袭或病毒性细胞病变。患者在诊断为皮肤转移后约8个月死亡。自1986年首次报告以来，仅有6例尿路上皮癌的带状疱疹样皮肤转移。我们回顾了先前的文献，包括带状疱疹样皮肤转移的发病机理的假设，仍然不完全理解。
