PDF(Pubmed)
Abstract：
The evidence for the incubation period of Legionnaires\' disease is based on data from a small number of outbreaks. An incubation period of 2-10 days is commonly used for the definition and investigation of cases. In the German LeTriWa study, we collaborated with public health departments to identify evidence-based sources of exposure among cases of Legionnaires\' disease within 1-14 days before symptom onset. For each individual, we assigned weights to the numbered days of exposure before symptom onset, giving the highest weight to exposure days of cases with only one possible day of exposure. We then calculated an incubation period distribution where the median was 5 days and the mode was 6 days. The cumulative distribution reached 89% by the 10th day before symptom onset. One case-patient with immunosuppression had a single day of exposure to the likely infection source only 1 day before symptom onset. Overall, our results support the 2- to 10-day incubation period used in case definition, investigation, and surveillance of cases with Legionnaires\' disease.
摘要：
军团病潜伏期的证据是基于少量爆发的数据。2-10天的潜伏期通常用于病例的定义和调查。在德国LeTriWa的研究中，我们与公共卫生部门合作,在症状出现前1-14天内确定军团病病例中基于证据的暴露源.对于每个人来说，我们将权重分配给症状发作前的暴露天数，对只有一天可能暴露的病例给予最高权重。然后，我们计算了潜伏期分布，其中中位数为5天，模式为6天。到症状发作前第10天，累积分布达到89％。一名免疫抑制患者在症状发作前仅1天暴露于可能的感染源。总的来说,我们的结果支持病例定义中使用的2至10天潜伏期，调查,以及对军团病病例的监测。
