Abstract：
Waldenström\'s macroglobulinemia (WM) is an immunoglobulin M monoclonal gammopathy produced by a bone marrow lymphoplasmacytic lymphoma, an indolent non-Hodgkin lymphoma in which the cure is still an unmet challenge. Combinations with alkylating agents, purine analogs, and monoclonal antibodies, Bruton tyrosine kinase, and proteasome inhibitors are used for the treatment of relapsed and refractory patients. Moreover, new additional agents can be seen on the horizon as potential effective therapies. No consensus on a preferred treatment in the relapsed setting is available yet.
摘要：
Waldenström巨球蛋白血症（WM）是由骨髓淋巴浆细胞淋巴瘤产生的免疫球蛋白M单克隆丙种球蛋白病，一种惰性的非霍奇金淋巴瘤，其中治愈仍然是一个未解决的挑战。与烷化剂的组合，嘌呤类似物,和单克隆抗体，布鲁顿酪氨酸激酶，和蛋白酶体抑制剂用于治疗复发和难治性患者。此外，新的额外药物可以被视为潜在的有效疗法。目前尚无关于复发情况下的优选治疗的共识。
