PDF(Pubmed)
Abstract：
CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins) family of proteins consists of six extracellular matrix (ECM)-associated proteins that regulate development, cell adhesion and proliferation, ECM remodeling, inflammation, and tumorigenesis. In the last two decades, metabolic regulation by these matricellular proteins has been studied extensively, several excellent reviews have covered the roles of CCN1, -2 and - 5. In this brief review, we will focus on those lesser-known members and more recent discoveries, together with other recent articles presenting a more complete picture of the current state of knowledge. We have found that CCN2, -4, and - 5 promote pancreatic islet function, while CCN3 plays a unique and negative role. CCN3 and - 4 are pro-adiposity leading to insulin resistance, but CCN5 and - 6 are anti-adiposity. While CCN2 and - 4 promote tissue fibrosis and inflammation, all other four members are clearly anti-fibrotic. As for cellular signaling, they are known to interact with integrins, other cell membrane proteins and ECM thereby regulate Akt/protein kinase B, myocardin-related transcription factor (MRTF), and focal adhesion kinase. Yet, a cohesive mechanism of action to comprehensively explain those major functions is still lacking.
摘要：
CCN/WISP(蜂窝通信网络因素，或Wnt诱导的分泌蛋白）蛋白家族由六种调节发育的细胞外基质（ECM）相关蛋白组成，细胞粘附和增殖，ECM重塑，炎症,和肿瘤发生。在过去的二十年里，这些基质细胞蛋白的代谢调节已经被广泛研究，一些优秀的评论涵盖了CCN1，-2和-5的作用。在这个简短的审查，我们将关注那些鲜为人知的成员和最近的发现，以及其他最近的文章，更全面地介绍了当前的知识状况。我们发现CCN2、-4和-5促进胰岛功能，CCN3发挥着独特的负面作用。CCN3和-4是导致胰岛素抵抗的促肥胖，但CCN5和-6是抗肥胖的。虽然CCN2和-4促进组织纤维化和炎症，所有其他四个成员明显抗纤维化。至于细胞信号,已知它们与整合素相互作用，其他细胞膜蛋白和ECM从而调节Akt/蛋白激酶B，心肌素相关转录因子（MRTF），和粘着斑激酶。然而，仍然缺乏一个统一的机制来全面解释这些主要功能。
