Abstract：
Programmed cell death pathways play important roles in a wide variety of physiological processes. Although it has similarities with apoptosis pyroptosis is a different type of programmed cell death. Pyroptosis can be triggered by different molecules originating from the cells or their environment. Once a pyroptotic pathway is started, it is followed by different molecular steps, and, it ends with the disruption of cell membrane integrity and the onset of inflammatory processes. In addition to the role of pyroptosis in the host\'s innate immunity against pathogens, uncontrolled pyroptosis can lead to increased inflammation and lead various diseases. The contradictory role of pyroptosis-related molecular changes in the pathogenesis of cancer has attracted attention lately. Excessive or decreased expression of molecules involved in pyroptotic pathways is associated with various cancers. There are ongoing studies on the use of different treatment methods for cancer in combination with new therapies targeting pyroptosis. The potential beneficial effects or side-effect profiles of these protocols targeting pyroptosis still need to be investigated. This will provide us with more efficient and safer options to treat cancer. This review aims to overview the main pathways and mechanisms of pyroptosis and to discuss its role in cancer.
摘要：
细胞程序性死亡途径在多种生理过程中起重要作用。虽然它与细胞凋亡有相似之处，焦亡是一种不同类型的程序性细胞死亡。可以通过源自细胞或其环境的不同分子来触发焦亡。一旦热解途径开始，然后是不同的分子步骤，and,它以细胞膜完整性的破坏和炎症过程的开始结束。除了焦亡在宿主对病原体的先天免疫中的作用，不受控制的焦亡可导致炎症增加并导致各种疾病。近年来，焦凋亡相关的分子变化在癌症发病机制中的矛盾作用引起了人们的关注。参与热解途径的分子的过度或降低的表达与各种癌症有关。目前正在研究使用不同的癌症治疗方法与靶向焦亡的新疗法相结合。仍需要研究这些靶向焦亡的方案的潜在有益作用或副作用概况。这将为我们提供更有效，更安全的癌症治疗选择。本文旨在概述焦亡的主要途径和机制，并讨论其在癌症中的作用。
