Abstract:
Background and objective: Inflammatory bowel disease (IBD), including Crohn\'s disease and ulcerative colitis, is a chronic inflammatory disorder characterized by aberrant immune responses and compromised barrier function in the gastrointestinal tract. IBD is associated with altered gut microbiota and their metabolites in the colon. Butyrate, a gut microbial metabolite, plays a crucial role in regulating immune function, epithelial barrier function, and intestinal homeostasis. In this review, we aim to present an overview of butyrate synthesis and metabolism and the mechanism of action of butyrate in maintaining intestinal homeostasis and to discuss the therapeutic implications of butyrate in IBD. Methods: We searched the literature up to March 2023 through PubMed, Web of Science, and other sources using search terms such as butyrate, inflammation, IBD, Crohn\'s disease, and ulcerative colitis. Clinical studies in patients and preclinical studies in rodent models of IBD were included in the summary of the therapeutic implications of butyrate. Results: Research in the last two decades has shown the beneficial effects of butyrate on gut immune function and epithelial barrier function. Most of the preclinical and clinical studies have shown the positive effect of butyrate oral supplements in reducing inflammation and maintaining remission in colitis animal models and IBD patients. However, butyrate enema showed mixed effects. Butyrogenic diets, including germinated barley foodstuff and oat bran, are found to increase fecal butyrate concentrations and reduce the disease activity index in both animal models and IBD patients. Conclusions: The current literature suggests that butyrate is a potential add-on therapy to reduce inflammation and maintain IBD remission. Further clinical studies are needed to determine if butyrate administration alone is an effective therapeutic treatment for IBD.
摘要:
背景与目的:炎症性肠病(IBD),包括克罗恩病和溃疡性结肠炎,是一种慢性炎性疾病,其特征在于胃肠道中异常的免疫应答和受损的屏障功能。IBD与结肠中肠道微生物群及其代谢产物的改变有关。丁酸,肠道微生物代谢产物,在调节免疫功能中起着至关重要的作用,上皮屏障功能,和肠道稳态。在这次审查中,我们旨在概述丁酸盐的合成和代谢以及丁酸盐在维持肠道稳态中的作用机制,并讨论丁酸盐在IBD中的治疗意义。方法:我们通过PubMed搜索了截至2023年3月的文献,WebofScience,以及其他使用诸如丁酸盐之类的搜索词的来源,炎症,IBD,克罗恩病,和溃疡性结肠炎.患者的临床研究和IBD啮齿动物模型的临床前研究包括在丁酸盐的治疗意义的总结中。结果:近二十年的研究表明丁酸对肠道免疫功能和上皮屏障功能的有益作用。大多数临床前和临床研究表明,丁酸盐口服补充剂在减轻结肠炎动物模型和IBD患者的炎症和维持缓解方面具有积极作用。然而,丁酸灌肠显示混合效应。产丁酸饮食,包括发芽的大麦食品和燕麦麸,在动物模型和IBD患者中发现增加粪便丁酸盐浓度并降低疾病活动指数。结论:目前的文献表明丁酸盐是减少炎症和维持IBD缓解的潜在附加疗法。需要进一步的临床研究来确定单独施用丁酸盐是否是IBD的有效治疗性治疗。