PDF(Pubmed)
Abstract：
Sudden cardiac death represents the leading cause of death worldwide; although the majority of sudden deaths occur in an elderly population with coronary artery disease, some occur in young and otherwise healthy individuals, as is the case of cardiomyopathies. The aim of the present review is to provide a stepwise hierarchical approach for the global sudden death risk estimation in primary cardiomyopathies. Each individual risk factor is analyzed for its contribution to the overall risk of sudden death for each specific cardiomyopathy as well as across all primary myocardial diseases. This stepwise hierarchical and personalized approach starts from the clinical evaluation, subsequently passes through the role of electrocardiographic monitoring and multimodality imaging, and finally concludes with genetic evaluation and electro-anatomical mapping. In fact, the sudden cardiac death risk assessment in cardiomyopathies depends on a multiparametric approach. Moreover, current indications for ventricular arrhythmia ablation and defibrillator implantation are discussed.
摘要：
心源性猝死是全球死亡的主要原因；尽管大多数猝死发生在患有冠状动脉疾病的老年人群，有些发生在年轻和其他健康的个体中，心肌病也是如此。本综述的目的是为原发性心肌病的全球猝死风险评估提供逐步分层的方法。分析每个单独的风险因素对每个特定心肌病以及所有原发性心肌病的猝死总体风险的贡献。这种逐步分层和个性化的方法从临床评估开始，随后通过心电图监测和多模态成像的作用，最后是遗传评估和电解剖图谱。事实上,心肌病的心源性猝死风险评估依赖于多参数方法.此外，讨论了室性心律失常消融和除颤器植入的当前适应症。
