PDF(Pubmed)
Abstract：
Emerging data suggest an increasing prevalence of persistent symptoms in individuals affected by coronavirus disease-19 (COVID-19). The objective of this study was to determine the relative frequency of altered taste and smell in COVID reinfection (multiple COVID positive tests) and long COVID (one COVID positive test). We sent an electronic survey to patients in the Indiana University Health COVID registry with positive COVID test results, querying if they were experiencing symptoms consistent with long COVID including altered chemosensory perceptions. Among the 225 respondents, a greater long COVID burden and COVID reinfection was observed in women. Joint pain was reported as the most common symptom experienced by 18% of individuals in the long COVID cohort. In the COVID reinfection cohort >20% of individuals reported headache, joint pain, and cough. Taste perception worse than pre-COVID was reported by 29% and 42% of individuals in the long COVID and COVID reinfection cohorts, respectively. Smell perception worse than pre-COVID was reported by 37% and 46% of individuals in long COVID and COVID reinfection cohorts, respectively. Further, Chi-square test suggested significant association between pre-COVID severity of taste/smell perception and headache in both cohorts. Our findings highlight the prevalence of persistent chemosensory dysfunction for two years and longer in long COVID and COVID reinfection.
摘要：
新数据表明，受冠状病毒病-19(COVID-19)影响的个体中持续症状的患病率增加。这项研究的目的是确定COVID再感染（多次COVID阳性测试）和长时间COVID（一次COVID阳性测试）中味觉和嗅觉改变的相对频率。我们向印第安纳大学健康COVID注册中心的患者发送了一份电子调查，COVID检测结果为阳性，询问他们是否正在经历与长期COVID一致的症状，包括改变的化学感知力。在225名受访者中，在女性中观察到更大的长期COVID负担和COVID再感染。据报道，在长期COVID队列中，有18%的人经历过最常见的症状是关节痛。在COVID再感染队列中，>20%的人报告头痛，关节痛,还有咳嗽.在长期COVID和COVID再感染队列中，分别有29％和42％的人报告了味觉感知比COVID之前差，分别。在长期COVID和COVID再感染队列中，分别有37%和46%的人报告气味感知比COVID前更差，分别。Further,卡方检验表明，在两个队列中，COVID前味觉/嗅觉感知的严重程度与头痛之间存在显着关联。我们的发现强调了在长期COVID和COVID再感染中持续两年或更长时间的化学感觉功能障碍的患病率。
