PDF(Pubmed)
Abstract：
The aim of this study was to assess the morpho-functional involvement of the retinal ganglion cells (RGCs) and of the visual pathways in patients with superficial (ODD-S) or deep (ODD-D) optic disc drusen. This study enrolled 17 patients with ODD (mean age of 59.10 ± 12.68 years) providing 19 eyes and 20 control subjects (mean age 58.62 ± 8.77 years) providing 20 eyes. We evaluated the following: best-corrected visual acuity, visual field mean deviation (MD), the amplitude (A) of Pattern Electroretinogram (PERG), the implicit time (IT) and A of Visual Evoked Potentials (VEPs), retinal nerve fiber layer thickness (RNFL-T) and ganglion cell thickness (GC-T). In ODD-S eyes, the drusen visible height was measured. ODD-D and ODD-S were detected in 26.3% and 73.7% of ODD eyes, respectively. Significantly (p < 0.01) reduced MD, PERG A, VEP amplitude, RNFL-T and GC-T values and significantly (p < 0.01) increased VEP IT values were found in the ODD Group as compared to the Control one. In the ODD Group, no significant correlation (p > 0.01) between PERG As and VEP ITs was found. In ODD-S, the visible height was significantly correlated (p < 0.01) with reduced MD, PERG As and RNFL-T and with increased PSD and VEP IT values. Our findings suggest that ODD might induce morpho-functional changes in RGCs and their fibers and an unrelated visual pathway dysfunction leading or not leading to visual field defects. The observed morpho-functional impairment should be ascribed to an alteration in retrograde (from the axons to the RGCs) and anterograde (from the RGCs up to the visual cortex) axoplasmic transport. In ODD-S eyes, a minimum visible height of 300 microns represented the threshold for the abnormalities, suggesting that \"the higher the ODD, the worse the impairment\".
摘要：
这项研究的目的是评估浅层（ODD-S）或深层（ODD-D）视盘玻璃疣患者的视网膜神经节细胞（RGC）和视觉通路的形态功能参与。这项研究招募了17名ODD患者（平均年龄为59.10±12.68岁），提供19只眼和20名对照受试者（平均年龄58.62±8.77岁），提供20只眼。我们评估了以下内容：最佳矫正视力，视野平均偏差(MD)，模式视网膜电图(PERG)的振幅(A)，隐含时间(IT)和视觉诱发电位(VEP)的A，视网膜神经纤维层厚度（RNFL-T）和神经节细胞厚度（GC-T）。在ODD-S眼中,测量玻璃疣的可见高度。在26.3％和73.7％的ODD眼中检测到ODD-D和ODD-S，分别。显著（p<0.01）降低MD，A级,VEP振幅,与对照相比,在ODD组中发现RNFL-T和GC-T值以及显著(p<0.01)增加的VEPIT值。在ODD组中，PERGAs与VEPITs之间没有发现显着相关性（p>0.01）。在ODD-S中,可见身高与MD降低显著相关(p<0.01),PERGAs和RNFL-T以及增加的PSD和VEPIT值。我们的发现表明，ODD可能会引起RGC及其纤维的形态功能变化，以及导致或不导致视野缺陷的无关视觉通路功能障碍。观察到的形态功能损害应归因于逆行（从轴突到RGC）和顺行（从RGC到视觉皮层）轴质运输的改变。在ODD-S眼中,300微米的最小可见高度代表异常的阈值，这表明“奇数越高，减值越严重。“
