Abstract:
The aim of this study was to assess the morpho-functional involvement of the retinal ganglion cells (RGCs) and of the visual pathways in patients with superficial (ODD-S) or deep (ODD-D) optic disc drusen. This study enrolled 17 patients with ODD (mean age of 59.10 ± 12.68 years) providing 19 eyes and 20 control subjects (mean age 58.62 ± 8.77 years) providing 20 eyes. We evaluated the following: best-corrected visual acuity, visual field mean deviation (MD), the amplitude (A) of Pattern Electroretinogram (PERG), the implicit time (IT) and A of Visual Evoked Potentials (VEPs), retinal nerve fiber layer thickness (RNFL-T) and ganglion cell thickness (GC-T). In ODD-S eyes, the drusen visible height was measured. ODD-D and ODD-S were detected in 26.3% and 73.7% of ODD eyes, respectively. Significantly (p < 0.01) reduced MD, PERG A, VEP amplitude, RNFL-T and GC-T values and significantly (p < 0.01) increased VEP IT values were found in the ODD Group as compared to the Control one. In the ODD Group, no significant correlation (p > 0.01) between PERG As and VEP ITs was found. In ODD-S, the visible height was significantly correlated (p < 0.01) with reduced MD, PERG As and RNFL-T and with increased PSD and VEP IT values. Our findings suggest that ODD might induce morpho-functional changes in RGCs and their fibers and an unrelated visual pathway dysfunction leading or not leading to visual field defects. The observed morpho-functional impairment should be ascribed to an alteration in retrograde (from the axons to the RGCs) and anterograde (from the RGCs up to the visual cortex) axoplasmic transport. In ODD-S eyes, a minimum visible height of 300 microns represented the threshold for the abnormalities, suggesting that \"the higher the ODD, the worse the impairment\".
摘要:
这项研究的目的是评估浅层(ODD-S)或深层(ODD-D)视盘玻璃疣患者的视网膜神经节细胞(RGC)和视觉通路的形态功能参与。这项研究招募了17名ODD患者(平均年龄为59.10±12.68岁),提供19只眼和20名对照受试者(平均年龄58.62±8.77岁),提供20只眼。我们评估了以下内容:最佳矫正视力,视野平均偏差(MD),模式视网膜电图(PERG)的振幅(A),隐含时间(IT)和视觉诱发电位(VEP)的A,视网膜神经纤维层厚度(RNFL-T)和神经节细胞厚度(GC-T)。在ODD-S眼中,测量玻璃疣的可见高度。在26.3%和73.7%的ODD眼中检测到ODD-D和ODD-S,分别。显著(p<0.01)降低MD,A级,VEP振幅,与对照相比,在ODD组中发现RNFL-T和GC-T值以及显著(p<0.01)增加的VEPIT值。在ODD组中,PERGAs与VEPITs之间没有发现显着相关性(p>0.01)。在ODD-S中,可见身高与MD降低显著相关(p<0.01),PERGAs和RNFL-T以及增加的PSD和VEPIT值。我们的发现表明,ODD可能会引起RGC及其纤维的形态功能变化,以及导致或不导致视野缺陷的无关视觉通路功能障碍。观察到的形态功能损害应归因于逆行(从轴突到RGC)和顺行(从RGC到视觉皮层)轴质运输的改变。在ODD-S眼中,300微米的最小可见高度代表异常的阈值,这表明“奇数越高,减值越严重。“