关键词: albuminuria angiotensin receptor blockers hypertension type 2 diabetes mellitus

来  源:   DOI:10.3390/jcm12103403   PDF(Pubmed)

Abstract:
Hypertension and type 2 diabetes mellitus (T2DM) are important, intertwined public health issues. People with both conditions face significantly elevated risks of cardiovascular (CV) and renal complications. To optimize patient care, a multidisciplinary expert panel met to review recent evidence on optimal blood pressure (BP) targets, implications of albuminuria, and treatment regimens for hypertensive patients with T2DM, with the aim of providing recommendations for physicians in Hong Kong. The panel reviewed the relevant literature, obtained by searching PubMed for the publication period from January 2015 to June 2021, to address five discussion areas: (i) BP targets based on CV/renal benefits; (ii) management of isolated systolic or diastolic hypertension; (iii) roles of angiotensin II receptor blockers; (iv) implications of albuminuria for CV/renal events and treatment choices; and (v) roles and tools of screening for microalbuminuria. The panel held three virtual meetings using a modified Delphi method to address the discussion areas. After each meeting, consensus statements were derived and anonymously voted on by every panelist. A total of 17 consensus statements were formulated based on recent evidence and expert insights regarding cardioprotection and renoprotection for hypertensive patients with T2DM.
摘要:
高血压和2型糖尿病(T2DM)是重要的,公共健康问题交织在一起。患有这两种疾病的人面临心血管(CV)和肾脏并发症的风险显着升高。为了优化患者护理,一个多学科专家小组举行会议,审查有关最佳血压(BP)目标的最新证据,白蛋白尿的影响,高血压合并T2DM患者的治疗方案,目的是为香港的医生提供建议。小组审查了相关文献,通过检索PubMed获得了2015年1月至2021年6月的发表期,以解决五个讨论领域:(i)基于CV/肾脏益处的BP目标;(ii)单纯性收缩期或舒张期高血压的管理;(iii)血管紧张素II受体阻滞剂的作用;(iv)白蛋白尿对CV/肾脏事件和治疗选择的影响;(v)微量白蛋白尿筛查的作用和工具.小组使用改进的Delphi方法举行了三个虚拟会议,以解决讨论领域。每次会议之后,每个小组成员都得出共识声明并匿名投票。根据最近的证据和有关T2DM高血压患者的心脏保护和肾脏保护的专家见解,总共制定了17项共识声明。
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