PDF(Pubmed)
Abstract：
For acute and chronic soft tissue infections, radical surgical debridement is required and is considered the gold standard, along with its immediate systemic antibiotic therapy. Treatment with local antibiotics and/or antibiotic-containing materials is commonly used as an additional tool in clinical practice. Spraying with fibrin and antibiotics is a newer technique that has been studied for some antibiotics. However, for gentamicin, data are not yet available on absorption, optimal application, antibiotic fate at the site and transfer of antibiotic into the blood. In an animal study involving 29 Sprague Dawley rats, 116 back wounds were sprayed with gentamicin using either gentamicin alone or one of two possible spray combinations of gentamicin and fibrin. Simultaneous application of gentamicin and fibrin via a spray system to soft tissue wounds resulted in significant antibiotic concentration over a long period of time. The technique is easy and cost-effective. The systemic crossover was significantly minimized in our study, which may have led to fewer side effects in patients. These results could lead to an improvement in local antibiotic therapy.
摘要：
对于急性和慢性软组织感染，根治性手术清创术是必需的，被认为是黄金标准，以及立即的全身抗生素治疗。用局部抗生素和/或含抗生素的材料进行治疗通常在临床实践中用作附加工具。用纤维蛋白和抗生素喷雾是一种较新的技术，已针对某些抗生素进行了研究。然而,对于庆大霉素，目前尚无吸收数据，最佳应用，抗生素在该部位的命运和抗生素进入血液的转移。在一项涉及29只SpragueDawley大鼠的动物研究中，使用单独的庆大霉素或庆大霉素和纤维蛋白的两种可能的喷雾组合之一用庆大霉素对116个背部伤口进行喷雾。通过喷雾系统将庆大霉素和纤维蛋白同时应用于软组织伤口会在长时间内产生显着的抗生素浓度。该技术简单且成本有效。在我们的研究中，系统交叉显著减少，这可能会减少患者的副作用。这些结果可能导致局部抗生素治疗的改善。
