PDF(Pubmed)
Abstract：
This review provides an overview of conventional and novel retinal imaging modalities for hydroxychloroquine (HCQ) retinopathy. HCQ retinopathy is a form of toxic retinopathy resulting from HCQ use for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Each imaging modality detects a different aspect of HCQ retinopathy and shows a unique complement of structural changes. Conventionally, spectral-domain optical coherence tomography (SD-OCT), which shows loss or attenuation of the outer retina and/or retinal pigment epithelium-Bruch\'s membrane complex, and fundus autofluorescence (FAF), which shows parafoveal or pericentral abnormalities, are used to assess HCQ retinopathy. Additionally, several variations of OCT (retinal and choroidal thickness measurements, choroidal vascularity index, widefield OCT, en face imaging, minimum intensity analysis, and artificial intelligence techniques) and FAF techniques (quantitative FAF, near-infrared FAF, fluorescence lifetime imaging ophthalmoscopy, and widefield FAF) have been applied to assess HCQ retinopathy. Other novel retinal imaging techniques that are being studied for early detection of HCQ retinopathy include OCT angiography, multicolour imaging, adaptive optics, and retromode imaging, although further testing is required for validation.
摘要：
这篇综述概述了羟氯喹（HCQ）视网膜病变的常规和新型视网膜成像方式。HCQ视网膜病变是由HCQ用于各种自身免疫性疾病引起的毒性视网膜病变的一种形式。如类风湿性关节炎和系统性红斑狼疮。每种成像模式检测HCQ视网膜病变的不同方面，并显示出结构变化的独特补充。传统上,频域光学相干层析成像(SD-OCT),这表明外视网膜和/或视网膜色素上皮-布鲁赫膜复合物的损失或衰减，和眼底自发荧光（FAF），显示旁凹或中央异常，用于评估HCQ视网膜病变。此外,OCT的几种变化(视网膜和脉络膜厚度测量，脉络膜血管分布指数,宽场OCT,恩面部成像，最小强度分析，和人工智能技术)和FAF技术(定量FAF，近红外FAF,荧光寿命成像检眼镜,和宽场FAF）已用于评估HCQ视网膜病变。正在研究用于早期检测HCQ视网膜病变的其他新型视网膜成像技术包括OCT血管造影，多色成像,自适应光学,和逆行成像，尽管验证需要进一步测试。
