PDF(Pubmed)
Abstract：
The geometrical details and biomechanical relationships of the mitral valve-left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.
摘要：
二尖瓣-左心室装置的几何细节和生物力学关系非常复杂，几十年来一直是研究领域。当生物力学和机械生物学条件的恢复成为主要目标时，这些特征在确定和完善治疗该系统疾病的最佳方法中起着重要作用。多年来,工程方法有助于在这方面彻底改变该领域。此外，先进的建模模式为新型设备和侵入性较小的策略的开发做出了巨大贡献。本文对二尖瓣治疗的发展进行了概述和叙述，特别关注心脏外科医师和介入心脏病学家经常遇到的两种疾病：缺血性和退行性二尖瓣返流。
