PDF(Pubmed)
Abstract：
(1) Background: Inhibitory and rewarding processes that mediate attentional biases to addiction-related cues may slightly differ between patients suffering from alcohol use (AUD) or gambling (GD) disorder. (2) Methods: 23 AUD inpatients, 19 GD patients, and 22 healthy controls performed four separate Go/NoGo tasks, in, respectively, an alcohol, gambling, food, and neutral long-lasting cueing context during the recording of event-related potentials (ERPs). (3) Results: AUD patients showed a poorer inhibitory performance than controls (slower response latencies, lower N2d, and delayed P3d components). In addition, AUD patients showed a preserved inhibitory performance in the alcohol-related context (but a more disrupted one in the food-related context), while GD patients showed a specific inhibitory deficit in the game-related context, both indexed by N2d amplitude modulations. (4) Conclusions: Despite sharing common addiction-related mechanisms, AUD and GD patients showed different patterns of response to (non-)rewarding cues that should be taken into account in the therapeutic context.
摘要：
（1）背景：在患有酒精使用（AUD）或赌博（GD）障碍的患者之间，介导对成瘾相关线索的注意力偏见的抑制性和奖励性过程可能略有不同。（2）方法：23名AUD住院患者，19例GD患者，22个健康对照执行了四个独立的Go/NoGo任务，in,分别,酒精,赌博,食物,和事件相关电位（ERP）记录期间的中性持久提示上下文。（3）结果：AUD患者表现出比对照组更差的抑制性能（反应潜伏期较慢，下N2d,和延迟的P3d组件)。此外,AUD患者在与酒精相关的环境中表现出保留的抑制性能（但在与食物相关的环境中更受干扰），虽然GD患者在游戏相关的背景下表现出特定的抑制缺陷，两者都由N2d振幅调制索引。(4)结论：尽管有共同的成瘾相关机制，AUD和GD患者对治疗背景中应考虑的(非)奖励线索显示出不同的反应模式。
