Abstract：
Cyclin-dependent kinase 16 (CDK16) is an orphan \"cyclin-dependent kinase\" (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers.
摘要：
细胞周期蛋白依赖性激酶16(CDK16)是参与细胞周期的孤儿“细胞周期蛋白依赖性激酶”(CDK),囊泡贩运，主轴方向,骨骼肌发生，神经突生长，分泌型货物运输，精子发生，葡萄糖运输，细胞凋亡，细胞生长和增殖，转移,和自噬。人类CDK16位于染色体Xp11.3上，与X连锁先天性疾病有关。CDK16通常在哺乳动物组织中表达并且可以充当癌蛋白。它是一种PCTAIRE激酶，其中CyclinY或其同源物，细胞周期蛋白Y样1通过与CDK16的N和C末端区域结合来调节活性。CDK16在各种癌症中起着至关重要的作用，包括肺癌,前列腺癌,乳腺癌,恶性黑色素瘤,和肝细胞癌。CDK16是癌症诊断和预后的有前途的生物标志物。在这次审查中,我们总结并讨论了CDK16在人类癌症中的作用和机制。
